Expression of MUC1 in different tumours and its clinical …
MUC1-Tn antigen is an oversimplified mucin-1 O-glycan that is overexpressed in different cancer types. For example, the study found that MUC1-Tn was abnormally expressed in breast, lung …
MUC1-Tn-targeting chimeric antigen receptor-modified Vγ9Vδ2 …
Jan 1, 2021 · In this study, we investigated the antigen-specific antitumor activity of CAR-Vγ9Vδ2 T cells targeting MUC1-Tn antigen. Vγ9Vδ2 T cells were expanded from peripheral blood …
Potential of Anti-MUC1 Antibodies as a Targeted Therapy for ...
In this review we present an overview of the antibodies targeting MUC1 in GI cancers, their potential role in immunotherapy (i.e., antibody-drug and radioimmunoconjugates, CAR-T …
Products of Chemoenzymatic Synthesis Representing MUC1 Tandem …
Nov 12, 2019 · Three STn-glycopeptides (MUC1 STn-Thr 8, MUC1 STn-Thr 13 and MUC1 STn-Thr 20) were synthesised with ST6GalNAc1 from each corresponding Tn glycopeptide in a …
Phase I experience with first in class TnMUC1 targeted chimeric …
May 28, 2021 · We have generated a novel chimeric antigen receptor (CAR) targeting the TnMUC antigen comprised of a mouse anti-human scFv derived from the monoclonal antibody 5E5 …
A novel Tn antigen epitope-recognizing antibody for MUC1 …
MUC1-Tn is specific for lung cancer cells and can improve diagnostic capabilities. Additionally, it may be a potential therapeutic target in lung ADC. Keywords: Tn antigen; epithelial …
Engineered CAR T Cells Targeting the Cancer-Associated Tn ... - PubMed
Jun 21, 2016 · We developed a CAR that recognized cancer-associated Tn glycoform of MUC1, a neoantigen expressed in a variety of cancers. Anti-Tn-MUC1 CAR T cells demonstrated target …
Chemoenzymatically synthesized multimeric Tn/STn MUC1 …
Oct 5, 2005 · In this study, we have developed chemoenzymatic synthesis of extended MUC1 TR glycopeptides with cancer-associated O-glycosylation using a panel of recombinant human …
Engineered CAR T Cells Targeting the Cancer-Associated Tn …
Jun 21, 2016 · We developed a CAR that recognized cancer-associated Tn glycoform of MUC1, a neoantigen expressed in a variety of cancers. Anti-Tn-MUC1 CAR T cells demonstrated target …
The Breast Cancer-Associated Glycoforms of MUC1, MUC1-Tn and sialyl-Tn ...
May 7, 2015 · Two glyco-epitopes that are found expressed by many carcinomas are Tn (GalNAc-Ser/Thr) and STn (NeuAc α 2,6GalNAc-Ser/Thr). These glycans can be carried on many …