The μ-opioid receptors (MOR) are a class of opioid receptors with a high affinity for enkephalins and beta-endorphin, but a low affinity for dynorphins. They are also referred to as μ (mu)-opioid peptide (MOP) receptors.

Jun 8, 2024 · These receptors primarily affect nociception but also stress, temperature, respiration, endocrine activity, gastrointestinal activity, memory, mood, and motivation. Because these receptors bind opioids, they are also commonly referred to as mu-opioid receptors (MORs).

Most of the potent analgesics currently in use act through the mu opioid receptor. Although they are classified as mu opioids, clinical experience suggests differences among them. The relative potencies of the agents can vary from patient to patient, as well as the side-effect profiles.

Opioid receptors are classified as μ (mu, MOP), δ (delta, DOP) and κ (kappa, KOP); these are naloxone-sensitive and possess endogenous peptide ligands. The fourth opioid receptor is that for nociceptin/orphanin FQ (N/OFQ) or NOP and is naloxone-insensitive.

Mu-opioid receptor genes have been identified in over 30 different species ranging from nonmammalian vertebrates such as white suckerfish and frog to a wide range of mammals .

Jul 24, 2023 · Exogenous opioids like morphine, heroin, and fentanyl are substances that are introduced into the body and bind to the same receptors as the endogenous opioids. To date, five types of opioid receptors have been discovered-mu receptor (MOR), kappa receptor (KOR), delta receptor (DOR), nociception receptor (NOR) and zeta receptor (ZOR).

Sep 24, 2018 · Mu opioid receptor agonists are among the most powerful analgesic medications but also among the most addictive. The current opioid crisis has energized a quest to develop opioid analgesics that...

Oct 27, 2020 · The mu-opioid receptor (MOR) is the cellular mediator of the effects of most commonly used opioids, and is a prototypical G protein-coupled receptor (GPCR) where new pharmacological, signalling and cell biology concepts have been coined.

Mu opioid receptors mediate positive reinforcement following direct (morphine) or indirect (alcohol, cannabinoids, nicotine) activation, and our understanding of mu receptor function is central to the development of addiction therapies.

The mu-opioid receptor (MOR) is the cellular mediator of the effects of most commonly used opioids, and is a prototypical G protein-coupled receptor (GPCR) where new pharmacological, signalling and cell biology concepts have been coined.