Methylthioadenosine phosphorylase deficiency in tumors: A …
MTAP loss leads to hypomethylation of PROM1/CD133-related stemness networks to mediate glioma stem-like cell formation, providing a promising therapeutic opportunity for GBM …
MTAP loss: a possible therapeutic approach for glioblastoma
Dec 26, 2022 · In this article, we review the loss of the 5′-methylthioadenosine phosphorylase (MTAP) gene as a potential therapeutic approach for treating glioblastoma. MTAP encodes a …
MTAP deficiency creates an exploitable target for antifolate
Apr 4, 2022 · Methylthioadenosine phosphorylase, an essential enzyme for the adenine salvage pathway, is often deficient (MTAP def) in tumors with 9p21 loss and hypothetically renders …
Prevalence of S-methyl-5′-thioadenosine Phosphorylase (MTAP) …
Loss of S-methyl-5′-thioadenosine phosphorylase (MTAP) expression is a common event in cancer leading to a critical vulnerability of cancer cells towards anti-cancer drugs. …
Methylthioadenosine Phosphorylase Genomic Loss in Advanced ...
Jun 3, 2024 · MTAP-loss is a developing drug target through synthetic lethality with MAT2A and PMRT5 inhibitors. The purpose of this study is to investigate the prevalence and genomic …
In this article, we review the loss of the 5′-methylthioadenosine phosphorylase (MTAP) gene as a potential therapeutic approach for treating glioblastoma. MTAP encodes a metabolic enzyme …
Deficiency of MTAP Is Frequent and Mostly Homogeneous in
Apr 1, 2025 · MTAP expression loss was homogenous in 37.6% and heterogeneous in 1.1% of the 181 tumors, with at least three evaluable samples on the heterogeneity TMA. On whole …
Genomic classification of clinically advanced pancreatic ductal ...
Jan 19, 2022 · Preclinically, MTAP loss leads to the accumulation of 2-methylthioadenosine, reduced protein arginine N-methyltransferase 5 (PRMT5) methylation activity and increased …
MTAP loss: a possible therapeutic approach for glioblastoma
In this article, we review the loss of the 5′-methylthioadenosine phosphorylase (MTAP) gene as a potential therapeutic approach for treating glioblastoma. MTAP encodes a metabolic enzyme …
Methylthioadenosine Phosphorylase Genomic Loss in Advanced ...
Feb 8, 2024 · MTAP -loss is a developing drug target through synthetic lethality with MAT2A and PMRT5 inhibitors. The purpose of this study is to investigate the prevalence and genomic …