An interactive resource tool for T helper type 2 (Th2) Cell Markers that includes links to related antibodies and data showcasing the detection of Th2 cells.

Although multiple cell types were shown to produce IL-10, its identity as a Th2 cytokine remained strong since it was rigidly associated with Th2 clones in mice, whereas both Th1 and Th2 clones could secrete IL-10 in humans.

The Mouse Th1/Th2 Cytokine Standards contain a mixture of individually lyophilized recombinant proteins made up of recombinant mouse Interleukin (IL)-2, IL-4, IL-5, Interferon-γ (IFN-γ), and Tumor Necrosis Factor (TNF).

Feb 28, 2023 · By generating and utilizing mouse strains that are deficient in either ILC2s or Th2 cells, we report that interleukin (IL)-33-mediated ILC2 activation promotes the Th2 cell response to papain; however, the Th2 cell response to ovalbumin (OVA)/alum immunization is thymic stromal lymphopoietin (TSLP) dependent but independent of ILC2s.

The BD Mouse Th1/Th2/Th17 Phenotyping Kit provides an easy-to-use four-color cocktail of fluorescent antibodies-specific for mouse CD4, IFN-γ (for Th1), IL-4 (for Th2) and IL-17A (for Th17)-that will enable researchers to identify and characterize the nature of these T helper cell types by multicolor flow cytometric analysis.

Here, we present a dynamic transcriptome analysis following Th-cell differentiation into Th1, Th2, and Th1/2 hybrid cells at 3-h time intervals in the first hours after stimulation.

We have studied the actions of helper T lymphocyte-1 and -2 (Th1 and Th2) cells in an acute model of eosinophilic airway inflammation by infusing chicken ovalbumin-specific (OVA-specific) Th1 cells, Th2 cells, or both into unsensitized mice and challenging the mice with an OVA aerosol.

Although surface expression and functionality of CCR4 are induced depending on the IL-4/STAT6 signaling pathway, the present results indicate that the functionality of CCR4 does not correlate with CCR4 expression but emerges at later stages of Th2 differentiation.

This application protocol describes a complete workflow for reliable and efficient mouse T H cell differentiation, starting with single-cell preparation, followed by isolation of naive CD4 + T cells and in vitro activation and differentiation, through to comprehensive cell analysis.