These mice may be useful for studying the mechanisms of IFN-induced and STAT1-dependant resistance to infection. Homozygous ( Stat1 -/- ) mice are viable and fertile when maintained …

Signal transducer and activator of transcription 1 (STAT1) is a transcription factor which in humans is encoded by the STAT1 gene. It is a member of the STAT protein family. [5]

STAT1 activates the transcription of genes with crucial antiviral properties, and the selective gene deletion of STAT1 in mice or the presence of loss-of-function mutations of STAT1 in humans …

Mar 8, 2025 · Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in cell population proliferation; cell surface receptor signaling pathway via JAK-STAT; …

Feb 9, 1996 · To study the requirement for STAT1 in vivo, we disrupted the Stat1 gene in embryonic stem (ES) cells and in mice. Stat1 (-1-)ES cells were unresponsive to interferon …

Mar 30, 2025 · STAT1 (Signal Transducer And Activator Of Transcription 1) is a Protein Coding gene. Diseases associated with STAT1 include Immunodeficiency 31C and Immunodeficiency …

We also show excellent efficacy of a selective STAT1 inhibitor fludarabine against TBI-induced functional deficits and brain injury using a mouse model, presenting STAT1 as a promising …

Feb 9, 1996 · To study the requirement for STAT1 in vivo, we disrupted the Stat1 gene in embryonic stem (ES) cells and in mice. Stat1−/− ES cells were unresponsive to interferon …

Feb 9, 1996 · Here we report the generation and characterization of mice deficient in STAT1. STAT1-deficient mice show no overt developmental abnormalities, but display a complete lack …

Mar 18, 2025 · View mouse Stat1 Chr1:52158599-52201024 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression