We found that mice injected i.v. with an autoantigen peptide of myelin oligodendrocyte glycoprotein (MOG) developed less severe experimental autoimmune encephalomyelitis (EAE) following immunization with MOG peptide but presented with more CD11c + CD11b + DCs in the CNS and spleen.

Jun 19, 2020 · In the lung, alveolar macrophages (AMs) are CD45 + Siglec F + CD11b − and are also positive for CD11c. Interstitial macrophages in the lung are F4/80 + Ly6C − , and can be further divided into MHCII + and MHCII − populations.

Sep 30, 2015 · In mice, lung innate immune cell alterations during endotoxin challenge, influenza virus infection, and in two genetic models of chronic obstructive lung disease could be segregated based on the...

Jan 1, 2006 · We investigated the role of CD11c- and CD11b-expressing leukocytes in T gondii transport during the early step of parasitism from the mouse small intestine and during subsequent parasite localization in the brain.

We now describe the identification of a novel CD11c + CD11b − Gr-1 + B220 + DC type present within mouse LN and spleen. These cells appear as immature plasmacytoid cells when freshly isolated but develop a dendritic morphology and the capacity to stimulate T cell proliferation after activation with CpG.

Aug 9, 2022 · Dermal cDC2 are characterized from the CD64 – Ly-6C – population by gating on CD11c + MHC-II + cells that express CD11b and CD172a (Fig. 2E). In addition, we investigated CD115, F4/80 and CD64 expression on the non-DC myeloid cell populations P1-P5 (Fig. 2F ).

For example, CD11c+ dendritic cells have been used in antibody therapies in mouse models. These cells can be targeted specifically using CD11c monoclonal antibodies from NeoBiotechnologies, offering a promising approach for treating various diseases.

The HistoSure CD11c antibodies are mouse-specific, i.e. they do not cross-react with human CD11c and are therefore particularly suited to distinguish murine from human cells in humanized mouse models.

Jan 1, 2013 · To better characterize DC responses, we have analyzed CD11c expression on mouse and human myeloid DC after Toll-like receptor (TLR) triggering. Here we show that mouse bone marrow-derived DC (BMDC) as well as spleen DC down-regulate cell surface CD11c upon activation by TLR3/4/9 agonists.

Age-associated B cells (ABC), a novel subset of activated B cells defined by CD11b and CD11c expression, have been linked with both protective anti-viral responses and the pathogenesis of systemic autoimmunity.