A Morpholino, also known as a Morpholino oligomer and as a phosphorodiamidate Morpholino oligomer (PMO), is a type of oligomer molecule (colloquially, an oligo) used in molecular biology to modify gene expression.

Apr 12, 2021 · A morpholino is a synthetic oligomer molecule that contains DNA bases on a methylene morpholine backbone. The name comes from morpholine oligomer.

Morpholino oligonucleotides are stable, uncharged, water‐soluble molecules used to block complementary sequences of RNA, preventing processing, read‐through, or protein binding at those sites. Morpholinos are typically used to block translation of ...

Morpholino antisense oligonucleotides are common used to transient knockdown of gene expression by blocking translation of a targeted protein. Morpholinos can be designed by Gene tools (Philomath, OR).

Mar 26, 2005 · Morpholino is an antisense oligonucleotide modified to be more stable than RNA. While morpholinos have standard nucleic acid bases, those bases are bound to morpholine rings instead of deoxyribose rings and linked through phosphorodiamidate groups instead of …

A Morpholino Oligonucleotide is a type of antisense oligonucleotide commonly used in neuroscience to temporarily reduce the expression of specific genes by inhibiting the translation of targeted proteins.

Feb 11, 2025 · Explore the latest advancements in morpholino chemistry, focusing on synthesis, structural innovations, and hybridization mechanisms.