Nonhuman primates are strong and dextrous and will remove the IV catheter by chewing or pulling if this is not done. The femoral vein and artery are the preferred site for blood sample collection in nonhuman primates.

Summary: Continuous intravenous infusion allows the intended clinical dosing regime to be better evaluated during preclinical studies. Depending on the test material and vehicle, infusion for up to 6 months in primates and 12 months in beagle dogs is possible, but 28 days is …

Feb 28, 2022 · When substances are given by IV infusion, the volume should not exceed 5% of the circulating blood volume over 2 hours or 4 ml/kg/h. The maximum recommended injection volume for a dosing solution that is given rapidly IV is 1 …

In the present study, we investigated the effects of the intravenous infusion, vest wearing, and repeated bleeding on hematology parameters, clinical chemistry parameters, C-reactive protein (CRP), and human cardiac troponin I (hsTnI) in cynomolgus monkeys.

Feb 21, 2025 · If no heartbeat can be heard or no pulses felt, then epinephrine should be given IV (see chart below). Reversal drugs should be given if opioids or xylazine have been used.

5–10 mg/kg, PO, four times daily for monkeys and marmosets for mild analgesia and pyrexia. May be used in conjunction with ibuprofen, PO. a All are extra-label uses.

Xin et al. described the development of MNRP1685A, a human mAb against neuropilin-1 (NRP1), where the PK in monkeys underestimated the nonspecific clearance in humans. 79 The PK of MNRP1685A was evaluated in mouse, rat, monkey, and humans following IV administration across a wide dose range.

Drug self-administration is a procedure in which a subject performs a response, called an operant, that results in the delivery of a drug injection. This procedure is viewed as a relevant model for the study of human drug-taking behavior.

Aug 8, 2008 · We have carried out a series of studies designed to ascertain the major inputs and outputs of the macaque monkey hippocampal formation. The initial studies focused on the entorhinal cortex, which was thought to be the major interface for cortical-hippocampal interconnections.

We demonstrate applications of a single, intravenous dose of CAP-Mac to deliver functional GCaMP for ex vivo calcium imaging across multiple brain areas, or a cocktail of fluorescent reporters for...