Melvin Abdul Noble Jr. (May 31, 1992 – November 11, 2020), known professionally as MO3, was an American rapper and singer from Dallas, Texas.

Mar 30, 2025 · MOB3A (MOB Kinase Activator 3A) is a Protein Coding gene. Diseases associated with MOB3A include Lung Occult Small Cell Carcinoma. An important paralog of this gene is MOB3B. May regulate the activity of kinases. ( MOB3A_HUMAN,Q96BX8 ) ... The sequence AAC27672.1 differs from that shown. Reason: …

MOB3A is a member of the MOB family of proteins that is capable of bypassing BRAF (164757) and RAS (HRAS; 190020) oncogene-induced senescence (OIS) by engaging the Hippo pathway (see YAP1, 606608) (Dutchak et al., 2022).

MOB3 is a MOB1 antagonist by inhibiting MST1 . MOB4/Phocein-MST4, part of the STRIPAK complex, also antagonizes MOB1, by disrupting MOB1-MST1/1 binding [ 34 ]. MOB1 interacts in a HsMOB1-PPP6R1/2/3-ANKRD28 complex which appears to inhibit MOB1 mediated Hippo activation and in a DOCK6/7/8-CRLF3-LRCH3/4 complex, in a phosphorylation dependent ...

Aug 1, 2023 · To address this, we undertook a proximity-dependent biotin identification approach to define the interactomes of all seven human MOB proteins in HeLa and human embryonic kidney 293 cell lines. We uncovered >200 interactions, of which at …

May 4, 2022 · Screening a library of activated kinases and kinase-regulatory proteins we identified MOB3A, a Mps-one binder coactivator (MOB) protein family member, whose constitutive expression permits proliferation and suppresses senescence …

MOBs represent globular scaffold proteins without any known enzymatic activities. They can act as signal transducers in essential intracellular pathways. MOBs have diverse cancer-associated cellular functions through regulatory interactions with members of the NDR/LATS kinase family.

Jan 19, 2022 · Screening a library of activated kinases and kinase-regulatory proteins we identified MOB3A, a Mps-one binder coactivator (MOB) protein family member, whose constitutive expression...

Description. The MOB3A (MOB kinase activator 3A) is a protein-coding gene located on chromosome 19. MOB3A may play a role in regulating the activity of kinases, suggesting its involvement in cellular signaling pathways.

In addition, Mob3, a small molecular weight protein of the Mob family (also known as phocein or preimplantation antigen 3), stably assembles with striatin (B‴) molecules, PP2Ac, and PP2A A in a complex containing at least four proteins (15, 16).