Nov 19, 2015 · Here, we report a novel, fast and ultrasensitive MMP activatable optical imaging probe for the dynamic visualization of MMP activity in photothrombotic stroke mice.

Jan 19, 2012 · Inhibition of p38MAPK blocked TGF-β1-increased mRNA expression of all MMPs and MMP inhibitors analyzed, and prevented TGF-β1 upregulation of TIMP-2 and MMP-2 proteins. Moreover, ERK1/2 inhibition increased RECK and prevented the TGF-β1 induction of pro-MMP-9 and TIMP-2 proteins.

Feb 5, 2025 · Rescue experiments validated the role of the S100A9/P38 MAPK/HSPB1 axis. Results: S100A9 was significantly upregulated in patients with AD, while levels of inflammatory cytokines and matrix metalloproteinases (MMPs) were elevated.

Matrix metalloproteinases (MMPs) are a family of zinc-dependent extracellular matrix (ECM) remodeling endopeptidases that have the capacity to degrade almost every component of the ECM. The degradation of the ECM is of great importance, since it is related to embryonic development and angiogenesis.

One group of phosphatases that has a regulatory role on the MAPK family are the mitogen-activated protein kinase phosphatases (MKPs) – family of at least 10 proteins which are capable of deactivating MAPKs by dephosphorylating both the threonine and tyrosine residues of MAPKs.

Jan 1, 2023 · MAPK and ERK1/2 activate the AP-1 factor through its nuclear translocation and binding to the AP-1 binding site that, in turn, can induce the gene transcription of MMPs.

Jul 19, 1999 · Mitogen-activated protein kinases (MAPKs) play a major role in the mitogenic signal transduction pathway and are essential components of both growth and differentiation. Constitutive activation of the MAPK cascade is associated with the carcinogenesis and metastasis of human breast and renal cell ca …

Feb 13, 2016 · Mitogen-activated protein kinase (MAPK) signaling pathway plays a key role in regulating OA process. Autophagy has an important effect on the OA process, and it is believed to be regulated by MAPKs.

Aug 30, 2002 · In this study, we have examined the specific roles of distinct MAPK signaling modules in regulation of the expression of endogenous MMP-1 and stromelysin-1 (MMP-3), a potent activator of latent MMP-1 in normal human skin fibroblasts.

The MAPK signaling cascades consist of three kinases: mitogen-activated protein kinase kinase kinase (MAPKKK), a mitogen-activated protein kinase kinase (MAPKK), and mitogen-activated protein kinase (MAPK) and results in proliferation, migration, differentiation, survival, or apoptosis.