Neutrophil collagenase, also known as matrix metalloproteinase-8 (MMP-8) or PMNL collagenase (MNL-CL), is a collagen cleaving enzyme which is present in the connective tissue of most mammals. [5] . In humans, the MMP-8 protein is encoded by the MMP8 gene. [6][7] The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [5] .

Mar 30, 2025 · MMP8 (Matrix Metallopeptidase 8) is a Protein Coding gene. Diseases associated with MMP8 include Preterm Premature Rupture Of The Membranes and Gingivitis. Among its related pathways are Matrix metalloproteinases and Innate Immune System.

Feb 7, 2024 · Here we show that expression of a circulating myeloid cell-specific proteinase, matrix metalloproteinase 8 (MMP8), is increased in the serum of humans with MDD as well as in...

The collective evidence reveals that in breast, skin and oral tongue cancer, MMP8 inhibits cancer cell invasion and proliferation, and protects patients from metastasis via cleavage of non-structural substrates. Conversely, in liver and gastric cancers, high levels of MMP8 worsen the prognosis.

Apr 1, 2024 · MMP-8 is involved in protein degradation through peptide bond hydrolysis and subsequently breaks down several collagens to contribute to several cellular and pathophysiological disease mechanisms [13]. Thus, MMP-8 may be taken into account as a potential therapeutic strategy for novel drug development. 2. Classification of MMPs.

Sep 11, 2019 · The collective evidence reveals that in breast, skin and oral tongue cancer, MMP8 inhibits cancer cell invasion and proliferation, and protects patients from metastasis via cleavage of non-structural substrates. Conversely, in liver and …

Jun 20, 2019 · In our previous study deriving the FAIM3:PLAC8 molecular biomarker, we noticed that MMP8, encoding matrix metalloproteinase-8 (MMP-8), was the most overexpressed gene in confirmed CAP relative to non-infectious differential diagnoses (no-CAP) [3].

The neutrophil collagenase matrix metalloproteinase-8 (MMP8) is a recently identified member of MMPs that have important roles in various inflammation-related disorders. Previously, we identified MMP8 as a new neuroinflammatory mediator in activated microglia by …

Gene ID: 4317, updated on 8-Feb-2025. This gene encodes a member of the matrix metalloproteinase (MMP) family of proteins. These proteins are involved in the breakdown of extracellular matrix in embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis.

Nov 14, 2024 · Title: Inhibition of MMP8 effectively alleviates manic-like behavior and reduces neuroinflammation by modulating astrocytic CEBPD. Correlations between different protein species of oral rinse MMP-8 and patient-related factors.