MMP-20, also known as enamelysin, appears to be the only MMP that is tooth-specific and it is expressed by cells of different developmental origin (i.e. epithelial ameloblasts and mesenchymal odontoblasts).

Mar 30, 2025 · MMP20 (Matrix Metallopeptidase 20) is a Protein Coding gene. Diseases associated with MMP20 include Amelogenesis Imperfecta, Hypomaturation Type, Iia2 and Amelogenesis Imperfecta Type 2. Among its related pathways are Collagen chain trimerization and Matrix metalloproteinases.

Significantly high expression levels of MMP20 and DSPP were observed in the malignant breast, colon, prostate, thyroid, and cervical neoplasms compared with their benign and normal counterparts. Furthermore, MMP20 levels increased with advanced stages of …

May 1, 2007 · Matrix metalloproteinase-20 (MMP20; enamelysin) is important for proteolytic processing of extracellular matrix (ECM) proteins during the formation of enamel and plays a critical role in proteolytic processing of amelogenin (AMEL), the …

Matrix metallopeptidase 20 (MMP20) is an evolutionarily conserved protease that is essential for processing enamel matrix proteins during dental enamel formation. MMP20 mutations cause human autosomal recessive pigmented hypomaturation‐type amelogenesis imperfecta (AI2A2; OMIM #612529).

Jul 11, 2016 · Matrix metalloproteinase-20 (MMP20) is expressed by ameloblasts in developing teeth and MMP20 mutations cause enamel malformation. We established a stably transfected Tet -Off Mmp20...

The MMP20 gene provides instructions for making a protein called enamelysin, which is essential for normal tooth development. Enamelysin is involved in the formation of enamel, which is the hard, white material that forms the protective outer layer of each tooth.

Dec 20, 2015 · Matrix metalloproteinase 20 (MMP20) and kallikrein‐related peptidase 4 (KLK4) are secreted proteinases that are essential for proper dental enamel formation.

Mar 20, 2015 · HGNC Approved Gene Symbol: MMP20. Cytogenetic location: 11q22.2 Genomic coordinates (GRCh38) : 11:102,576,832-102,625,332 (from NCBI) The matrix metalloproteinases (MMPs) are a group of structurally related zinc-dependent endopeptidases that mediate the degradation of extracellular matrix components.

Jan 4, 2025 · MMP20-generated amelogenin cleavage products prevent formation of fan-shaped enamel malformations. increased cadherin cleavage by transgenic MMP20 in the wild type background releases excess beta-catenin, which translocates to ameloblast nuclei to promote cell migration/invasion.