Matrix metalloproteinase-12 (MMP-12) also known as macrophage metalloelastase (MME) or macrophage elastase (ME) is an enzyme that in humans is encoded by the MMP12 gene. [5][6][7]

Mar 30, 2025 · Complete information for MMP12 gene (Protein Coding), Matrix Metallopeptidase 12, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium

As many metalloproteinases (MMPs), macrophage elastase (MMP-12) is able to degrade extracellular matrix components such as elastin and is involved in tissue remodeling processes.

Macrophage MMP12 regulates adipose tissue expansion, insulin sensitivity, and expression of inducible nitric oxide synthase. MMP12 is located in genes previously associated with chronic obstructive pulmonary disease susceptibility.

Oct 15, 2008 · Through the activity of macrophage-specific matrix metalloproteinase-12 (MMP-12), we found that macrophages dampen the lipopolysaccharide (LPS)-induced influx of polymorphonuclear leukocytes (PMNs)—thus providing a new mechanism for the termination of PMN recruitment in acute inflammation.

Here, we show that acute and chronic arterial stiffening in mice is accompanied by a striking induction of MMP12, a potent elastase, in vascular SMCs. We also show that MMP12 is essential for arterial stiffening in mice and is a highly prognostic marker of arterial stiffness in humans.

Feb 5, 2025 · MMP-12 is found in healthy adult tissues and possesses a limited cell distribution. Initially, it was thought to affect only tissue macrophages and not the circulating monocytes. It …

Jul 18, 2018 · Matrix metalloproteinase 12 (MMP12), a protease involved in macrophage migration, could also have a crucial role in regulating the resolution of inflammation. The results of a new study...

Oct 23, 2014 · We show that macrophage MMP12 promotes resolution of inflammation by cleaving C3 to dampen complement activation, MMP12 inactivates C3a and C5a chemoattractants to reduce inflammatory cell infiltration, and together these activities act in concert with iC3b and C3b cleavage, which increases phagocytic clearance of apoptotic cells …

MMP12 mRNA is highly expressed in 13 cancers compared to their controls, and the MMP12 protein level is elevated in some of these cancers (e.g., colon adenocarcinoma) (P < .05). MMP12 expression makes it feasible to distinguish 21 cancer tissues from normal tissues (AUC = 0.86).