Apr 3, 2024 · Adeno-associated virus (AAV) has emerged as a pivotal delivery tool in clinical gene therapy owing to its minimal pathogenicity and ability to establish long-term gene expression in different...

Conventional methods to detect AAV vector transduction can miss transient or low levels of reporter expression. Here the authors use editing-reporter mice and discover numerous sites of AAV targeting along with better prediction of the gene editing footprint.

Historically, adeno-associated virus (AAV)-defective interfering particles (DI) were known as abnormal virions arising from natural replication and encapsidation errors. Through single virion genome analysis, we revealed that a major category of DI ...

Here we present protocols for stereotaxic intracranial injection of AAV vectors in adult mice, intravenous delivery of AAV vectors via the superficial temporal vein and tail vein in neonatal and adult mice, respectively.

Jun 9, 2024 · Background: ANCA-associated vasculitis (AAV) is a rare but serious disease. Traditional case-identification methods using claims data can be time-intensive and may miss important subgroups. We hypothesized that a deep learning model analyzing electronic health records (EHR) can more accurately identify AAV cases.

Learn how our unique AAV solutions can help overcome these obstacles. We're here to help solve challenges in your research—just ask us! Viral genome titer measures the number of viral particles that contain the therapeutic gene.

This brochure explains what autoimmune conditions and AAV are, how AAV develops, and the different types. It also covers its signs, symptoms, as well as expert tips on recognizing and understanding the condition.

This review describes the applications of AAV vectors to cancer models and presents developments in vector engineering and payload design aimed at tailoring AAV vectors for transduction and treatment of cancer cells.

Sep 12, 2024 · Standardized evaluation of adeno-associated virus (AAV) vector products for biotherapeutic application is essential to ensure the safety and efficacy of gene therapies. This includes analyzing the critical quality attributes of the product.

Dec 8, 2022 · Our LC-MS method provides a sensitive, fast, and high-throughput 4-min run that allows for efficient characterization of wild-type and engineered AAV capsids.