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Combination with Pembrolizumab (PD-1) | Mirati Therapeutics, Inc.
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MRTX1719 was evaluated in biochemical assays that measure the inhibition of the PRMT5/MEP50 complex enzymatic activity using SAM as a methyl donor and a histone 4 …
MRTX Pan-KRAS SII Inhibitors Targets Susceptible WT KRAS and Susceptible Mutant Variants RKN (KRAS G12V) TGI-21 0 10 20 30 40 50 60 0 500 1000 1500
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Trial of Two Adagrasib Dosing Regimens in NSCLC With KRAS …
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Mocetinostat With Vinorelbine in Children, Adolescents & …
Mocetinostat With Vinorelbine in Children, Adolescents & Young Adults With Refractory and/or Recurrent Rhabdomyosarcoma
KRAS/MAPK Dependency in Cancer Frequency of KRAS mutations • Dysregulation of KRAS/MAPK pathway is one the most frequent causes of cancer >200K deaths in the US due …
Switch II Pocket GDP. Introduction. Co-Crystal Structure of 1 Reveals Key Interactions. MRTX1257 Selectively Modifies KRAS G12C in H358 Cells. MRTX1257 Demonstrated Robust …
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