Jul 12, 2023 · Our findings reveal a role of this arky GPe→DLS circuit in constraining habitual seeking in male mice, which is relevant to addictive behaviors and other compulsive disorders.

Here we studied the membrane properties, synaptic inputs, and sensory responses of these subpopulations in the mouse GPe. We performed in vivo whole-cell recordings in GPe neurons and used optogenetic stimulation to dissect their afferent inputs from …

Jun 19, 2023 · Mastro, K. J., Bouchard, R. S., Holt, H. A. K. & Gittis, A. H. Transgenic mouse lines subdivide external segment of the globus pallidus (GPe) neurons and reveal distinct GPe output pathways.

The GPe is extensively interconnected with the striatum, the subthalamic nucleus, and the internal globus pallidus, forming intricate feedback and feedforward loops. The GPe is primarily composed of two types of GABAergic neural populations, known as arkypallidal and prototypic neurons.

We present a classification method of the GPe neurons from wild‐type C57BL/6J mice based upon cluster analysis of the neuronal electrophysiological properties and compare these findings to characteristics of neurons in the molecular marker‐expressing mice.

May 8, 2017 · Here we demonstrate that, in DD mice, transiently dissociating the activity of PV-GPe and Lhx6-GPe subpopulations induces long-lasting recovery of movement and reversal of pathological...

Here, we use transgenic mouse lines to define two genetically distinct, non-overlapping populations of GPe neurons in healthy rodents.

We propose that the GPe GABAergic neurons should be classified into three subgroups: arkypallidal, low-firing prototypical and high-firing prototypical neurons. This work will help researchers identify GPe neuron subtypes when transgenic mice with labelled neurons cannot be …

Apr 27, 2023 · GPe activation improved ipsilateral circling, contralateral forelimb akinesia, locomotor hypoactivity, and bradykinesia in 6-OHDA-lesioned mice at ineffective photostimulation parameters (532 nm, 5 Hz, 3 mW) in normal mice.

Apr 27, 2023 · The findings show that global GPe photostimulation improves a range of motor deficits in 6-OHDA-lesioned mice. In normal mice, GPe photoinhibition had little effect on motor behavior but promoted cognitive functions.