Milk fat globule-EGF factor 8 protein (Mfge8), also known as lactadherin, is a protein that in humans is encoded by the MFGE8 gene. [5][6] Mfge8 is a secreted protein found in …

Mar 30, 2025 · Complete information for MFGE8 gene (Protein Coding), Milk Fat Globule EGF And Factor V/VIII Domain Containing, including: function, proteins, disorders, pathways, …

Milk fat globule-EGF factor 8 (MFG-E8) is expressed by macrophages and plays an important role in attenuating inflammation and maintaining tissue homeostasis. Previously, we and others …

Milk fat globule epidermal growth factor 8 (Mfge8) is a soluble glycoprotein known to regulate inflammation and immunity by mediating apoptotic cell clearance. Since fibrosis can occur as a …

Jan 1, 2014 · Mouse MFG-E8 binds specifically to the unfertilized oocytes, but not to that of fertilized eggs. Recombinant MFG-E8 and its F5/8-C domain fragment inhibit the sperm-egg …

Jan 19, 2014 · We show here that Mfge8 promotes the absorption of dietary triglycerides and the cellular uptake of fatty acid and that Mfge8-deficient (Mfge8−/−) mice are protected from diet …

Oct 17, 2023 · By binding to Integrin αVβ3/αVβ5 receptors, MFGE8 promotes tumor progression by activating both the PI3K/AKT and ERK/AKT pathways.

A rare missense variant in the milk fat globule-EGF factor 8 (MFGE8) increases T2DM susceptibility and cardiovascular disease risk with population-specific effects. The intergenic …

In this study, we aimed to investigate the role of milk fat globule‐EGF factor 8 (MFGE8), a kind of soluble glycoprotein, in TGF‐ β 1‐induced EndMT.

Milk fat globule-EGF-factor 8 (Mfge8) is a milk glycoprotein that is abundantly expressed in the mammary gland epithelium and has been shown to facilitate the clearance of apoptotic …