These αMHC-MerCreMer transgenic mice allow the creation of bitransgenic mice for Cre-lox studies of temporally regulated deletion of <i>loxP</i>-flanked targeted genes in cardiac tissues/cells.

The Cre-LoxP technology, including the tamoxifen (TAM) inducible MerCreMer (MCM), is increasingly used to delineate gene function, understand the disease mechanisms, and test therapeutic interventions. We set to determine the effects of …

The tamoxifen inducible Cre recombinase (MerCreMer) is a fusion protein containing Cre recombinase with two modified estrogen receptor ligand binding domains at both ends, and is driven by the neural-specific rat neural specific enolase (NSE) promoter.

To compare the labeling specificity Myh6-Cre with other similar Cre strains, we employed the inducible transgenic mouse line Myh6-MerCreMer that has been reported previously to target cardiomyocytes (Sohal et al. 2001).

The tamoxifen inducible Cre recombinase (MerCreMer) is a fusion protein containing Cre recombinase with two modified estrogen receptor ligand binding domains at both ends, and is driven by the neural-specific rat neural specific enolase (NSE) promoter.

032052 B6.129- Kit tm2.1(cre/Esr1*)Jmol /J Kit MCM mice express MerCreMer (cre/Esr*) tamoxifen-inducible cre recombinase from the mouse Kit (KIT proto-oncogene receptor tyrosine kinase) promoter. These mice have been useful in tracing the lineage of Kit …

Jul 6, 2001 · The most obvious application of the MerCreMer transgenic line is to promote temporally regulated deletion of loxP-targeted genes in vivo. However, the MerCreMer transgene can also be used to temporally regulate expression …

The H11-CAG-MerCreMer mouse is a tamoxifen-inducible tool mouse that ubiquitously expresses the MerCreMer recombinase under the control of the CAG promoter.

Cdh16-MerCreMer mice were generated by inserting a tamoxifen-inducible Cre recombinase protein (MerCreMer) expression element downstream of the stop codon of the mouse Cdh16 gene. The expression pattern of MerCreMer mirrored that of the endogenous gene, while not affecting its expression.

Jul 23, 2015 · Mhy6 encodes a cardiac muscle specific protein: alpha-myosin heavy chain. Here, we generated a new Myh6-MerCreMer (Myh6MerCreMer/+) inducible Cre knock-in mouse by inserting a MerCreMer cassette into the Myh6 start codon.