Mertk: An emerging target in cancer biology and immuno-oncology
The main ligands of Mertk are Vitamin K-modified endogenous proteins Gas6 and Protein S (ProS1), heterobifunctional modular proteins that bind Mertk via two carboxyl-terminal laminin …
MERTK Gene - GeneCards | MERTK Protein | MERTK Antibody
Mar 30, 2025 · MERTK (MER Proto-Oncogene, Tyrosine Kinase) is a Protein Coding gene. Diseases associated with MERTK include Retinitis Pigmentosa 38 and Retinitis Pigmentosa. …
MERTK - Tyrosine-protein kinase Mer - Homo sapiens (Human)
Nov 13, 2007 · Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. …
Focus on Molecules: MERTK - PMC
MERTK (UniProt accession Q12866) is a single pass transmembrane receptor that belongs to the TAM (T yro3, A xl and M ertk) family of receptor tyrosine kinases. MERTK is highly expressed …
MERTK protein expression summary - The Human Protein Atlas
Assigned HPA protein class (es) for the encoded protein (s). Number of protein-coding transcripts from the gene as defined by Ensembl. A summary of the overall protein expression profile …
Molecular Pathways: MERTK Signaling in Cancer - PMC
MERTK is a receptor tyrosine kinase of the TAM (Tyro3, Axl, MERTK) family, with a defined spectrum of normal expression. However, MERTK is over-expressed or ectopically expressed …
MERTK - Wikipedia
Proto-oncogene tyrosine-protein kinase MER is an enzyme that in humans is encoded by the MERTK gene. [5][6][7] This gene is a member of the TYRO3/AXL/MER (TAM) receptor kinase …
MERTK in cancer therapy: Targeting the receptor tyrosine kinase …
Sep 1, 2020 · In this review we discuss MERTK inhibition as an emerging strategy for cancer therapy, focusing on MERTK expression and function in neoplasia and its role in mediating …
MerTK is a mediator of alpha-synuclein fibril uptake by human
Feb 1, 2024 · Mer tyrosine kinase (MerTK) is a receptor tyrosine kinase that mediates non-inflammatory, homeostatic phagocytosis of diverse types of cellular debris. Highly expressed …
Shedding of the Mer tyrosine kinase receptor is mediated by …
Sep 23, 2011 · Mer tyrosine kinase (MerTK) is an integral membrane protein that is preferentially expressed by phagocytic cells, where it promotes efferocytosis and inhibits inflammatory …