Myeloid-derived suppressor cells (MDSCs) are a recently discovered bone-marrow-derived cell type. They have characteristic of immature stem cells with immunomodulatory properties.

Myeloid-derived suppressor cells (MDSC) are a diverse population of immature myeloid cells that have potent immune suppressive activity. Studies in both mice and humans have demonstrated that MDSC accumulate in most individuals with cancer where ...

MDSC consist of two large groups of cells termed granulocytic or polymorphonuclear (PMN-MDSC), which are phenotypically and morphologically similar to neutrophils; and monocytic (M-MDSC) – phenotypically and morphologically similar to monocytes.

Mar 19, 2021 · Myeloid-derived suppressor cells (MDSC) are pathologically activated neutrophils (PMN) and monocytes (Mon) with potent immune-suppressive activity. These cells have a distinct...

Jul 6, 2016 · Myeloid-derived suppressor cells (MDSCs) have emerged as major regulators of immune responses in cancer and other pathological conditions. In recent years, ample evidence supports key...

Oct 7, 2021 · Myeloid-derived suppressor cells (MDSCs), characterized by their suppressive effects on immune responses, are important motivators to promote tumor immune escape. MDSCs expand massively...

Recent studies describe a heterogeneous population of cells of the myeloid lineage, termed myeloid derived suppressor cells (MDSC), which are observed with increased prevalence in the peripheral blood and tumor microenvironment of cancer patients, including pancreatic cancer.

May 11, 2021 · Myeloid-derived suppressor cells (MDSCs) most commonly describe cells arising during chronic inflammation, especially late-stage cancers, and are defined by T cell immunosuppressive functions. Merad and colleagues discuss limitations to this MDSC concept and propose a framework that reclassifies MDSC within broader inflammatory cell states.

Jul 5, 2024 · Myeloid-derived suppressor cells (MDSCs) are cells of neutrophil and monocyte lineages with potent immunosuppressive activity. Numerous studies in mice and humans have identified important...

Myeloid-derived suppressor cells (MDSCs) are one of the most discussed biological entities in immunology. While the context and classification of this group of cells has evolved, MDSCs most commonly describe cells arising during chronic inflammation, especially late-stage cancers, and are defined by their T cell immuno-suppressive functions.