Mar 18, 2021 · In this study, we performed RNA sequencing of MDSCs derived from the spleen and tumor. Based on the results of our RNA-seq analysis, mitogen-activated protein kinases (MAPK) were significantly increased in tumor polymorphonuclear MDSCs (PMN-MDSCs) and monocytic MDSCs (M-MDSCs).

In this review we discuss the role played by key signaling pathways such as PI3K, Ras, Jak/Stat and TGFb during myeloid development and how their deregulation under pathological conditions can lead to the generation of suppressive myeloid cells or MDSCs.

Apr 23, 2021 · In coculture analysis, MDSCs, with the stimulation of IL-6, could significantly lower the proliferation ability of CD4 + or CD8 + T lymphocytes. Further, this study demonstrated that IL-6 could upregulate the mitogen-activated protein kinase (MAPK) signaling pathway in MDSCs.

Feb 1, 2021 · Myeloid-derived suppressor cells (MDSCs) are pathologically activated neutrophils and monocytes with potent immunosuppressive activity. They are implicated in the regulation of immune...

Jun 20, 2024 · We found that tumor MDSCs increase XPO1 expression through an IL-6-STAT3-dependent pathway. We showed that XPO1 blockade induces a shift in MDSC differentiation toward neutrophil-like cells with...

Mechanistically, activated hematopoietic stem cell (HSC) induced monocyte-intrinsic p38 mitogen-activated protein kinase (MAPK) signaling to trigger enhancer reprogramming for M-MDSC development and immunosuppression .

Further analysis revealed that the activation of nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) pathways recruited a large number of MDSCs via cytokines. Finally, MDSC secreted high levels of interleukin-10 and arginase-1 and created an immunosuppressive TIME.

Apr 1, 2022 · MAPK pathway, one of the sorafenib targets, is the downstream signaling of FGF1 and is reactivated by MDSCs-mediated FGF1 upregulation. Our finding demonstrated that MDSCs led to tumor growth and sorafenib resistance via FGF1 upregulation and subsequent indirect CAF activation.

In this study, we performed RNA sequencing of MDSCs derived from the spleen and tumor. Based on the results of our RNA-seq analysis, mitogen-activated protein kinases (MAPK) were significantly increased in tumor polymorphonuclear MDSCs (PMN-MDSCs) and monocytic MDSCs (M-MDSCs).

Oct 10, 2016 · Studies have reported that mitogen-activated protein kinase (MAPK) and nuclear factor kappa B (NF-κB) regulate cytokine secretion in MDSCs. 20 To investigate the downstream signals of the ...