The cytokine interleukin (IL)-6 was found to be a crucial regulator of MDSC accumulation and activation as well as a factor, stimulating tumor cell proliferation, survival, invasiveness and metastasis.

Our in vitro and ex vivo findings demonstrated that IL-6 induced CCR5 expression and a strong immunosuppressive activity of MDSC, highlighting this cytokine as a promising target for melanoma immunotherapy.

Jan 1, 2021 · This review discusses the pleiotropic effects of IL-6 on immune cell populations that are critical for tumor development, such as MDSC and T cells, and summarizes the data on targeting IL-6 or IL-6 receptor (IL-6R) for tumor immunotherapy to block MDSC-mediated immunosuppression in cancer patients.

Dec 15, 2017 · Interleukin-6 (IL-6) stimulated the sustained activation of the JAK/STAT pathway in myeloid-derived suppressor cells (MDSCs) displaying persistent phosphorylation of downstream STAT proteins. The activation status of the JAK/STAT pathway was measured using Western blot.

Apr 23, 2021 · This study was aimed at demonstrating that the levels of IL-6 and the number of myeloid-derived suppressor cells (MDSCs), with a positive correlation between them, increased in MIBC tissues, promoting MIBC cell proliferation, especially in patients with recurrence.

Jan 8, 2024 · The production of high levels of IL-6 by breast cancer cells has been shown to result in an intratumoural accumulation of MDSCs in mice, with IL-6 receptor shedding by tumour-expanded...

Myeloid-derived suppressor cells (MDSCs) accumulate and differentiate through tightly regulated by diverse signaling pathways (Fig. 1). Here, we highlight several key pathways, including STATs, C/EBP, and NF-κB.

These findings provide a unique insight into the role of IL-6 in the expansion of the MDSC population which causes inflammatory changes and increased Th-17 responses during ECM. Keywords: IL-6; Inflammation; Malaria; Myeloid derived suppressor cells; …

May 15, 2024 · In a cohort of patients with sarcoma and breast cancer, the production of interleukin-6 (IL-6) by tumor-infiltrating NK cells correlated with S100A8/9 and arginase-1 expression by MDSCs.

Peripheral blood monocytes acquire the phenotype of myeloid-derived suppressor cells (MDSCs) by induction of cytokine or co-culture with cancer cells and are widely used to model MDSCs for in vitro studies.