May 15, 2019 · Understanding how MDSC recruitment, activation, expansion, and differentiation occurs in the CNS could help develop future therapeutic strategies that are based on the …

PMN-MDSCs (polymorphonuclear myeloid-derived suppressor cells) have been characterized in the context of malignancies. Here we found that PMN-MDSCs had the unique ability to restrain …

Apr 1, 2022 · Results: TCGA data analysis of patients with grade IV glioma and oHSV treatment of experimental brain tumors in mice showed that NOTCH signaling significantly correlated …

The central nervous system (CNS) is an important system in the human body and has certain immune functions. Immune response in the CNS is relatively complex, and microglia play a …

Experimental autoimmune encephalomyelitis (EAE) is a commonly used mouse model of multiple sclerosis (MS), an autoimmune inflammatory disease of the CNS characterized by recurrent …

Dec 20, 2016 · The two MDSC subsets inhibit immune responses through different mechanisms: PNM-MDSCs suppress antigen (Ag)-specific CD8 + T cells mainly by producing reactive …

Myeloid-derived suppressor cells (MDSCs) are a recently discovered bone-marrow-derived cell type. They have characteristic of immature stem cells with immunomodulatory properties.

Multiple sclerosis (MS) is a highly heterogeneous demyelinating disease of the central nervous system (CNS) that needs for reliable biomarkers to foresee disease severity. Recently, …

In the present work, M-MDSC distribution was analysed by immunohistochemistry in CNS samples from 40 MS patients with different clinical course duration and 6 controls. We …

Apr 4, 2022 · Pharmacologic blockade of NOTCH signaling could overcome MDSC recruitment and immune suppression. This report uncovers the effect of NOTCH signaling in brain tumor …