Induced myeloid leukemia cell differentiation protein Mcl-1 is a protein that in humans is encoded by the MCL1 gene. [5][6] The protein encoded by this gene belongs to the Bcl-2 family. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have …

Sep 2, 2021 · Here, we synthesize studies characterizing MCL1s influence on cell proliferation, DNA damage response, autophagy, calcium handling, and mitochondrial quality control to highlight the broader...

Mar 30, 2025 · MCL1 (MCL1 Apoptosis Regulator, BCL2 Family Member) is a Protein Coding gene. Diseases associated with MCL1 include Myeloid Leukemia and Hematologic Cancer. Among its related pathways are Cytokine Signaling in Immune system and Signaling by ALK in …

Apr 4, 2024 · MCL-1 is essential for promoting the survival of many normal cell lineages and confers survival and chemoresistance in cancer. Beyond apoptosis regulation, MCL-1 has been linked to modulating mitochondrial metabolism, but the mechanism (s) by which it …

Myeloid cell leukemia-1 (MCL1), an antiapoptotic member of the BCL2 family characterized by a short half-life, functions as a rapid sensor that regulates cell death and other relevant processes that include cell cycle progression and mitochondrial homeostasis.

Jan 6, 2020 · MCL1 is the first antiapoptotic gene for which homology to BCL2 was reported. Mcl-1 plays a significant role in the inhibition of apoptosis and demonstrates oncogenic properties. Mcl-1 is a...

Mcl-1 is a Bcl-2 family protein which can act as an apical molecule in apoptosis control, promoting cell survival by interfering at an early stage in a cascade of events leading to release of cytochrome c from mitochondria.

Sep 2, 2021 · Here, we synthesize studies characterizing MCL1s influence on cell proliferation, DNA damage response, autophagy, calcium handling, and mitochondrial quality control to highlight the broader scope that MCL1 plays in cellular homeostasis regulation.

Sep 30, 2021 · Myeloid cell leukemia 1 (MCL-1) is an anti-apoptotic oncoprotein and one of the most investigated members of the BCL-2 family. It is commonly known to be genetically altered, aberrantly overexpressed, and primarily associated with …

Apr 25, 2019 · Myeloid cell leukemia-1 (MCL1) was the first reported gene found to be homologous to BCL2 and has since been shown by numerous studies to have an antiapoptotic role in the regulation of cell survival . However, the nature of Mcl-1 seems to be more complicated: its different splice variants play opposite roles in apoptosis, while its ...