Maspin is a member of the serpin superfamily of serine protease inhibitors. [5] The primary function of most members of this family is to regulate the breakdown of proteins by inhibiting the catalytic activity of proteinases.

Maspin (mammary serine protease inhibitor) was identified in 1994 by subtractive hybridization analysis of normal mammary tissue and breast cancer cell lines. Subsequently, emerging evidence portrays maspin as a multifaceted protein, interacting ...

Maspin regulates tumor cell motility, invasion, growth, and apoptosis. 2,3,4 It has also been identified as a regulator of angiogenesis. 5,40 Recently, several molecular targets for maspin have been discovered which include the integrins and, more controversially, the plasminogen activators uPA and tPA. 6,7,8 As the number of potential targets ...

Jul 1, 2012 · Maspin, a non-inhibitory member of the serine protease inhibitor superfamily, has been characterized as a tumor suppressor gene in multiple cancer types.

Maspin is a unique member of the serpin family that shares extensive homology with monocyte-neutrophil elastase inhibitor, 3 PAI-2 and other serpins. 13,14 Initially identified as a class II tumor suppressor gene, maspin has been shown to inhibit invasion and motility of mammary tumors. 13,15,16 Tumor transfectants expressing maspin exhibit ...

Maspin (mammary serine protease inhibitor), is a member of the serine protease inhibitor/non-inhibitor superfamily. Its expression is down-regulated in breast, prostate, gastric and melanoma cancers but over-expressed in pancreatic, gallbladder, ...

Dec 9, 2024 · Maspin is a member of the clade B serine protease inhibitor superfamily and exhibits diverse regulatory effects in various types of solid tumors. We compared the expressions of maspin and determined its potential biological functions and regulatory ...

Maspin, a non-inhibitory member of the serine protease inhibitor superfamily, has been characterized as a tumor suppressor gene in multiple cancer types. Among the established anti-tumor effects of Maspin are the inhibition of cancer cell invasion, attachment to extracellular matrices, increased sen …

Maspin (SERPINB5) is a 42 kDa serpin expressed predominantly in epithelial cells. You might find these chapters and articles relevant to this topic. Maspin is a recently identified protein related to the serpin family of protease inhibitors (Zou et al., 1994).

Jul 7, 2011 · Maspin is a non-inhibitory serine protease inhibitor (serpin) that influences many cellular functions including adhesion, migration, and invasion. The underlying molecular mechanisms that facilitate these actions are still being elucidated. In this study we determined the mechanism by which maspin mediates increased MCF10A cell adhesion.