Studies of fruit fly mushroom bodies have been particularly important for understanding the genetic basis of mushroom body functioning, since their genome has been sequenced and a vast number of tools to manipulate their gene expression exist.

The mushroom body (MB) is a computational center in the Drosophila brain. The intricate neural circuits of the mushroom body enable it to store associative memories and process sensory and internal state information.

Dec 23, 2014 · A map of the entire array of cell types and potential projections in the mushroom body of the fruit fly brain provides insights into the circuitry that supports learning of stimulus-reward and stimulus–punishment associations.

Jan 12, 2010 · Blocking mushroom body output alters a fly's sleep patterns, affecting the duration of sleep intervals. Perhaps the mushroom body can act as a gate, uncoupling sensory input from behavioral output during sleep.

Dec 14, 2020 · Here, we present a connectomic analysis of one such neuronal ensemble, the mushroom body (MB) of an adult Drosophila melanogaster. Understanding how memories of past events are formed and then used to influence ongoing behavior are key …

Sep 29, 2009 · Recent studies on the compartmentalization of fly mushroom bodies show that learning and memory in Drosophila are not as simple as might be expected for an organism with such a tiny brain.

Aug 8, 2022 · Associative memory formation and recall in the fruit fly Drosophila melanogaster is subserved by the mushroom body (MB). Upon arrival in the MB, sensory information undergoes a profound transformation from broadly tuned and stereotyped odorant responses in the olfactory projection neuron (PN) layer to narrowly tuned and nonstereotyped responses ...

The insect mushroom body (MB) may be a uniquely suitable structure for intervention. Its internal cytoarchitecture seems less complex than that of most other neuropil regions and its bizarre shape suggests a highly specialized function.

Apr 1, 2003 · Genetic intervention in the fly Drosophila melanogaster has provided strong evidence that the mushroom bodies of the insect brain act as the seat of a memory trace for odours.

Dec 23, 2014 · Output neurons in the mushroom body of the fruit fly brain encode the positive or negative survival value of stimuli, enabling insects to choose adaptive approach and avoidance behaviors through associative learning.