Apr 17, 2017 · Here, we demonstrate for the first time that Mycobacterium marinum induces both an early autophagic response and its simultaneous repression by blocking the autophagic digestion.

Mar 21, 2011 · In this report, we show an active interaction of M. marinum with the autophagic protein LC3, an event that requires pathogen viability and bacterial protein synthesis.

Apr 10, 2023 · We monitored infected cells by electron microscopy, showing that autophagy protects the host macrophage by partially reducing mycobacterial access to the cytosol. We conclude that autophagy has...

Apr 17, 2017 · Monitoring infection stages by genetics, pharmacology and microscopy, we demonstrate that the ESX-1 secretion system of Mycobacterium marinum, a close relative to M. tuberculosis, upregulates the transcription of autophagy genes, and stimulates autophagosome formation and recruitment to the mycobacteria-containing vacuole (MCV) in the host ...

Mar 11, 2025 · Remarkably, the mRNA vaccine induced autophagy in granulomas, coinciding with bacterial killing and cell survival. Collectively, these findings demonstrate that the mRNA vaccine elicits potent innate and adaptive immunity, providing effective host protection against mycobacterial challenge.

Feb 2, 2015 · Pathogenic mycobacteria can be transmitted by direct ejection from one host cell to another. However, the mechanism of ejection, and how lysing the host cell is prevented are unknown. This study explains how the host cell remains intact and alive while Mycobacterium marinum breaks through its plasma

In this report, we show an active interaction of M. marinum with the autophagic protein LC3, an event that requires pathogen viability and bacterial protein synthesis.

Mar 21, 2011 · In this report, we show an active interaction of M. marinum with the autophagic protein LC3, an event that requires pathogen viability and bacterial protein synthesis.

Mar 7, 2023 · DRAM1, standing for damage-regulated autophagy modulator 1, is the founding member of a family of five stress-inducible autophagy regulators [24,25]. DRAM1 functions as a target of p53 signalling in the UV-damage response and as a target of NF-κB signalling during Mm and Mtb infection [ 20 , 24 ].

Apr 17, 2017 · Our findings suggest that the infection by M. marinum activates an autophagic response that is simultaneously repressed and exploited by the bacterium to support its survival inside the MCV.