Mar 30, 2025 · Complete information for MAP3K7 gene (Protein Coding), Mitogen-Activated Protein Kinase Kinase Kinase 7, including: function, proteins, disorders, pathways, orthologs, and expression.

The mitogen‐activated protein 3 kinase 7 (MAP3K7) gene (MIM# 602614) encodes transforming growth factor β (TGF‐β)‐activated kinase 1 (TAK1), which plays a vital role in innate and adaptive immunity by regulating inflammatory responses and regulating cell differentiation, cell survival, and apoptosis (Dai et al., 2012; Yu et al., 2014 ...

Mitogen-activated protein kinase kinase kinase 7 (MAP3K7), also known as TAK1, is an enzyme that in humans is encoded by the MAP3K7 gene. [5] TAK1 is an evolutionarily conserved kinase in the MAP3 K family and clusters with the tyrosine-like and sterile kinase families.

MAP3K7 is an innate immune regulatory gene with increased expression in human and murine kidney intercalated cells following uropathogenic Escherichia coli exposure.

Mitogen-activated protein 3 kinase 7 (MAP3K7) encodes the ubiquitously expressed transforming growth factor β-activated kinase 1, which plays a crucial role in many cellular processes.

Feb 8, 2025 · In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses.

TGF-beta activated protein kinase (TAK1; official gene symbol MAP3K7) contains two highly conserved alternatively spliced exons of which one is enhanced by ESRP expression and the other is silenced. TGF-beta is a well-described inducer of the EMT through both SMAD-dependent and SMAD-independent pathways.

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway 1, 2, 3, 4, 5, 6, 7, 8. Plays an important role in the cascades of cellular responses evoked by changes in the environment 9, 10, 11, 12, 13, 14, 15, 16.

Feb 4, 2022 · HGNC Approved Gene Symbol: MAP3K7. Cytogenetic location: 6q15 Genomic coordinates (GRCh38) : 6:90,513,579-90,587,072 (from NCBI) The MAP kinase (MAPK) cascades constitute functional units that couple upstream input signals to a variety of outputs through pathways that involve 3 protein kinases.

Sep 1, 2021 · Activation of MAP3K7 (also termed TAK1) and downstream IκB kinase β (IKKβ) by proinflammatory cytokines such as TNFα stimulates NF-κB survival pathways. Paradoxically, MAP3K7 is often deleted in human prostate cancer.