Mitogen-activated protein kinase kinase kinase 3 is an enzyme that in humans is encoded by the MAP3K3 gene, [5] which is located on the long arm of chromosome 17 (17q23.3). [6] This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse MEKK3.

Mar 30, 2025 · MAP3K3 (Mitogen-Activated Protein Kinase Kinase Kinase 3) is a Protein Coding gene. Diseases associated with MAP3K3 include Cerebral Cavernous Malformations 5 and Verrucous Hemangioma. Among its related pathways are NGF Pathway and Interleukin-1 …

MAP3K3 directly regulates the MAPK8/JNK and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. [ 11 ] MAP3K7 (TAK1) participates in regulation of transcription by transforming growth factor-beta ( TGF-beta ).

MAP3K3 overexpression is an independent poor prognostic indicator in ovarian carcinoma. MAP3K3 may potentially not only serve as diagnostic/prognostic markers for patients with lung cancer but also provide an indicator for future investigations …

In this study, we confirmed the deregulation of MAP3K3 in human breast cancer cell lines and tumour tissue specimens, and further explored the role of this gene in breast tumourigenesis as well as in the response of breast cancer cells to cytotoxic chemo-drugs.

In vivo, MAP3K3 knockdown reduces IFN-I induction and increases the susceptibility to herpes simplex virus type 1 (HSV-1) infection. Endogenous MAP3K3 binds to and phosphorylates IRF7 upon the binding of TLR9 to its specific ligand CpG DNA.

Apr 16, 2024 · Here, we present a novel mechanism of YAP stability regulation by MAP3K3 that is independent of Hippo kinases. Furthermore, we identified MAP3K3 as a target for overcoming anticancer drug...

Jan 2, 2014 · MEKK3 is also called MAP3K3, a kinase capable of activating both the ERK and the stress-activated protein kinase cascades. It is positioned upstream of SEK and MEK in the signalling pathways and directly phosphorylates these enzymes.

Feb 8, 2025 · Mitogen activated protein kinase kinase kinase 3 (MAP3K3/MEKK3) overexpression is an early event in esophageal tumorigenesis and is a predictor of poor disease prognosis. Hasan R, Sharma R, Saraya A, Chattopadhyay TK, DattaGupta S, Walfish PG, Chauhan SS, Ralhan RHasan R, et al. BMC Cancer, 2014 Jan 2. PMID 24383423

Somatic mutations in MAP3K3 and PIK3CA were recently reported in patients with sporadic CCM, yet it remains unknown whether MAP3K3 mutation is sufficient to induce CCMs.