Maleimide is a chemical compound with the formula H 2 C 2 (CO) 2 NH (see diagram). This unsaturated imide is an important building block in organic synthesis. The name is a contraction of maleic acid and imide, the -C(O)NHC(O)- functional group.

Maleimide is a cyclic dicarboximide in which the two carboacyl groups on nitrogen together with the nitogen itself form a 1H-pyrrole-2,5-dione structure. It has a role as an EC 5.99.1.3 [DNA topoisomerase ( ATP -hydrolysing)] inhibitor.

Maleimide is a particularly versatile heterocycle and considerable effort has been expended in the last 10 years in attaching the group to polymers. By far the most prolific utilization of maleimide and its derivatives as pendant groups on polymers has been for the development of photosensitive materials.

Maleimide (2,5-Pyrroledione) is a new nanoparticle surface functional group which favors easy conjugation with cell penetration peptides. The conjugation is enabled via click chemistry to preserve its biofunctions. Maleimide is used as a dienophile in Diels Alder reaction for the synthesis of macromolecules.

ChemSpider record containing structure, synonyms, properties, vendors and database links for Maleimide, 541-59-3, 208-787-4, PEEHTFAAVSWFBL-UHFFFAOYSA-N

Aug 10, 2018 · Rational design of novel generations of maleimides and maleimide-type reagents have been reported to address the shortcomings of classical maleimides. This review highlights recent developments in the maleimide chemistry focused on bioconjugation strategies.

Jan 2, 2019 · Maleimide chemistry stands out in the bioconjugation toolbox by virtue of its synthetic accessibility, excellent reactivity, and practicability. The second-generation of clinically approved antibody-drug conjugates (ADC) and much of the current ADC pipeline in clinical trials contain the maleimide l …

Sep 7, 2014 · Here, we describe a solution to the instability of alkyl maleimide–derived conjugates through the incorporation of a basic functional group adjacent to the maleimide.

Maleimide; EC Number: 208-787-4 at Sigma-Aldrich. Research. Development. Production. We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and …

Here we demonstrate maleimide reacts with cysteine sulfinic acids in proteins. Using a sequential alkylation strategy, maleimide probes can selectively label protein sulfinic acids on chemical standards, recombinant protein, and in cell homogenates from stimulated cells.