Matrix-assisted laser desorption ionization/imaging mass spectrometry (MALDI IMS) with a time-of-flight analyzer was used to characterize the distribution of lipid molecular species in the …

MALDI-ion mobility (IM)-orthogonal time-of-flight mass spectrometry (oTOFMS) provides an advantage by initially separating different classes of biomolecules such as lipids, peptides, and …

Matrix assisted laser desorption/ionization mass spectrometry (MALDI-MS) is a powerful tool that has allowed researchers to directly probe tissue molecular structure and drug content with …

Jun 1, 2021 · Through the MALDI-MS imaging based on the pre-coated matrix, we detected more than 60 kinds of lipids and small molecules, including phospholipids, cyclic adenosine …

Target for MALDI imaging with two conductive-surface microscope slides. Sample preparation is a critical step in imaging spectroscopy. Scientists take thin tissue slices mounted on conductive …

Ischemia-mediated lipidomic changes in rat brains were explored by matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS) profiling and imaging after in situ …

Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) enables the localization and the structural identification of a large set of molecules on a surface with 10-20 …

Mar 6, 2024 · Principle of MALDI mass spectrometry imaging. (A) MALDI MS is performed in situ, where matrix-covered tissue sections are analyzed. Analyte ions are generated upon laser …

MALDI Imaging is a powerful mass spectrometry tool for mapping the distribution of molecules from a thin sample, ranging from small metabolites to large proteins, without molecular tags or …

Matrix-assisted laser desorption ionization/imaging mass spectrometry (MALDI IMS) with a time-of-flight analyzer was used to characterize the distribution of lipid molecular species in the …