Monoacylglycerol lipase (EC 3.1.1.23; systematic name glycerol-ester acylhydrolase, also known as MAG lipase, acylglycerol lipase, MAGL, MGL or MGLL) is an enzyme that, in humans, is …

Monoacylglycerol lipase (MAGL) has been characterized as the main enzyme responsible for the inactivation of the most abundant brain endocannabinoid, 2-arachidonoylglycerol (2-AG).

Dec 4, 2019 · Monoacylglycerol Lipase (MAGL) is the specialized enzyme that breaks down the endocannabinoid 2-AG, and it represents the point at which the endocannabinoid system …

Dec 5, 2023 · Monoacylglycerol lipase (MAGL) regulates endocannabinoid 2-arachidonoylglycerol (2-AG) and eicosanoid signalling. MAGL inhibition provides therapeutic opportunities but …

Monoacylglycerol lipase (MAGL) plays a crucial role catalysing the hydrolysis of monoglycerides. MAGL inhibitors have been considered as important agents in many therapeutic fields, …

Monoacylglycerol lipase (MAGL) is a key enzyme involved in the metabolism of 2-AG (2-arachidonoylglycerol), a neuroprotective endocannabinoid intimately linked to the generation …

Oct 21, 2016 · Monoacylglycerol lipase (MAGL) is a key enzyme in lipid metabolism that is demonstrated to be involved in tumor progression through both energy supply of fatty acid …

MAGL is a serine hydrolase that preferentially hydrolyzes monoacylglycerols to glycerol and fatty acid, with highest expression in brain, white adipose tissue, and liver in mice and is a soluble …

Monoacylglycerol lipase (MAGL) is the rate-limiting enzyme in the degradation of monoacylglycerols. It is a proinflammatory enzyme that metabolises 2-arachidonoylglycerol, …

Introduction: Monoacylglycerol lipase (MAGL) belongs to the endocannabinoid system and is responsible for the inactivation of endocannabinoid 2-arachidonoylglycerol.