Feb 1, 2020 · Macrolides are a class of drugs used to manage and treat various bacterial infections. Azithromycin, clarithromycin, and erythromycin are commonly used to treat infections like pneumonia, sinusitis, pharyngitis, and tonsillitis.

Macrolide suppression of proinflammatory cytokine production may be the principal mechanism of action in DPB (71, 183, 283). The working group of the Diffuse Lung Disease Committee of the Ministry of Health and Welfare of Japan prepared clinical …

Macrolide antibiotics inhibit protein synthesis by targeting the bacterial ribosome. They bind at the nascent peptide exit tunnel and partially occlude it. Thus, macrolides have been viewed as ‘tunnel plugs’ that stop synthesis of every protein.

Oct 25, 2023 · Macrolides are a group of antibiotics characterized by a macrocyclic lactone ring attached to various amino or neutral sugars. They are widely used in clinical medicine, particularly against respiratory pathogens and certain atypical organisms.

The macrolides bind to the 50S ribosomal subunit with a specific target in 23s ribosomal RNA molecule and various ribosomal proteins. All macrolides inhibit bacterial protein synthesis, …

Since erythromycin, clarithromycin and azithromycin are the most commonly described macrolide antibiotics, this review will focus on the pharmacokinetics, pharmacodynamics and pharmacogenomics of these three drugs (Figure 1).

In this review we summarize the current knowledge, as well as unsolved questions, regarding the principles of macrolide binding to the large ribosomal subunit and the mechanism of drug action.

Intracellular signal transduction pathways that have been proposed to be involved in macrolide immunomodulation. There are three major pathways that are influenced by macrolides. Receptor tyrosine kinases (RTKs) are receptors for many polypeptide growth factors and cytokines.

May 16, 2023 · Macrolides are a class of drugs used to manage and treat various bacterial infections. Azithromycin, clarithromycin, and erythromycin are commonly used to treat infections like pneumonia, sinusitis, pharyngitis, and tonsillitis.

Aug 23, 2019 · This chapter will introduce macrolides broadly, discuss the structure and mode of action of current macrolide antibiotics, detail the current clinical use of macrolides, and provide a view of future uses of macrolides, with a specific look at current challenges and new macrolides undergoing clinical trials.