MYH9 is a large gene spanning more than 106 kilo base pairs on chromosome 22q12.3. It is composed of 41 exons with the first ATG of the open reading frame localized in exon 2 and the stop codon in exon 41. It encodes non-muscle myosin heavy chain IIA (NMHC IIA), a protein of 1,960 amino acids.

The MYH9 gene encodes the heavy chain of non-muscle myosin IIA, a widely expressed cytoplasmic myosin that participates in a variety of processes requiring the generation of intracellular chemomechanical force and translocation of the actin cytoskeleton.

Feb 1, 2024 · Conversely, nucleosome assembly protein 1-like 5 (NAP1L5) downregulates MYH9, inhibits the PI3K/AKT/mTOR signaling pathway, suppresses the proliferation, migration, and invasion of hepatocellular carcinoma cells, and induces apoptosis [116].

Aug 27, 2024 · Phosphorylated MYH9 blocks myosin-IIA assembly and promotes breast cancer . Timeless protein, encoded by the clock gene TIMELESS is highly expressed in CRC tissues, and its high expression is associated with H3K27 acetylation in its promoter region.

Jan 29, 2019 · MYH9 is an isoform of the non-muscle II (NM II) family of proteins that includes NM IIA, NM IIB, and NM IIC 4. It is comprised of two heavy chains (230 kDa), two regulatory light chains (RLCs) (20 kDa), and two essential light chains (ELCs) (17 kDa) that mediates actin-based contractile motion.

Myosin heavy chain 9 (MYH9) encodes a protein called non-muscle myosin II (NMM-II), which belongs to the myosin superfamily. NMM-II is a hexamer composed of 2 heavy chains (220 kDa), 2 regulatory light chains (RLC, 20 kDa), and 2 essential light chains (ELC, 17 kDa).

MYH9 is a novel cancer stem cell marker and prognostic indicator in esophageal cancer that promotes oncogenesis through the PI3K/AKT/mTOR axis. Long Noncoding RNA TPRG1-AS1 Suppresses Migration of Vascular Smooth Muscle Cells and Attenuates Atherogenesis via Interacting With MYH9 Protein.

Mar 30, 2025 · MYH9 (Myosin Heavy Chain 9) is a Protein Coding gene. Diseases associated with MYH9 include Macrothrombocytopenia And Granulocyte Inclusions With Or Without Nephritis Or Sensorineural Hearing Loss and Deafness, Autosomal Dominant 17.

Jul 20, 2018 · This review discusses the structure of the MYH9 gene and its protein, as well as the regulation and physiologic functions of non-muscle myosin IIA with particular reference to embryonic development. Moreover, the review focuses on current knowledge about the role of MYH9 variants in human disease.

Jun 15, 2021 · During CRC cell invasion, ATG9B is transported to the cell edge with the assistance of MYH9 and accelerates focal adhesion (FA) assembly through mediating the interaction of endocytosed...