Myc is a family of regulator genes and proto-oncogenes that code for transcription factors. The Myc family consists of three related human genes: c-myc (MYC), l-myc (MYCL), and n-myc …

Here, we review the cumulative knowledge on Myc structure and biophysics and discuss the implications for its biological function and the development of improved Myc inhibitors.

We present a view of MYC as a sensor that integrates multiple cellular signals to mediate a broad transcriptional response controlling many aspects of cell behavior. We also describe the larger …

Mar 10, 2021 · Myc is comprised of three domains: NTD, central region, and CTD. Highly conserved elements, Myc boxes, are staggered across these domains and involved in the …

Sep 10, 2021 · MYC activation drives cancer progression through mechanisms involving either the cell-intrinsic acquisition of hallmarks of cancer or dysregulation of the tumour …

This review describes the main functional and structural features of the protein structure of MYC and provides a general overview of the most relevant or recently identified interactors that …

Functional analysis of Myc continues to strengthen connections to trans-criptional regulation. CTD interactions are growing in complexity, but, at a broad level of understanding, the new results …

Structural analyses of Myc show many critical regions with transient structures that mediate protein interactions and biological functions. Interactors, such as Max, TRRAP, and PTEF-b, …

Apr 1, 2018 · The c-MYC transcription factor is a master regulator of cell growth and proliferation and is an established target for cancer therapy. This basic helix-loop-helix Zip protein forms a …

Mar 30, 2025 · MYC (MYC Proto-Oncogene, BHLH Transcription Factor) is a Protein Coding gene. Diseases associated with MYC include Burkitt Lymphomaand High-Grade B-Cell …