In B cells, Myc acts as a classical oncogene by regulating a number of pro-proliferative and anti-apoptotic pathways, this also includes tuning of BCR signaling and CD40 signaling in …

Sep 10, 2021 · In the past few years, studies have demonstrated that MYC signalling can enable tumour cells to dysregulate their microenvironment and evade the host immune response. …

MYC is downstream of deregulated Notch signaling pathways found in T-cell leukemia (Palomero et al., 2006; Sharma et al., 2006; Weng et al., 2006). Hence, alterations of MYC are commonly …

Mar 25, 2023 · In this review, we summarize the essential role of the MYC signaling pathway in tumor immunity and the development status of MYC-related therapies, including therapeutic …

Mar 10, 2021 · Myc protein orchestrates diverse physiological processes, including cell proliferation, differentiation, survival, and apoptosis. Myc modulates about 15% of the global …

MYC is a master regulator of cell metabolism. In cells with deregulated MYC expression, key genes involved in cell growth and proliferation are robustly activated, resulting in tumorigenesis.

In the past few years, studies have demonstrated that MYC signalling can enable tumour cells to dysregulate their microenvironment and evade the host immune response. Herein, we discuss …

The capacity of c-Myc as a prognostic factor in brain tumors will be investigated. Our goal is to define an axis in which the c-Myc signaling pathway plays a crucial role and to provide …

In the past few years, studies have demonstrated that MYC signalling can enable tumour cells to dysregulate their microenvironment and evade the host immune response. Herein, we discuss …

Aug 9, 2021 · Both mature and immature BCR signaling cascades are able to increase the MYC expression. sIgM signaling increases the MYC mRNA stability, which results in a higher level …