MYC coordinates protein synthesis through the transcriptional control of RNA and protein components of ribosomes, and of gene products required for the processing of ribosomal …

We identify genes connected to mitochondrial function and ribosome biogenesis as direct MYC/HCF-1 targets and demonstrate how modulation of the MYC–HCF-1 interaction …

With this review we outlined the evidence of Myc in controlling ribosome biogenesis with its role in cell competition, a hypothesis that may connect the ability of Myc to initiate tumorigenesis by …

Jun 5, 2020 · One of the master regulators of ribosome biogenesis is Myc, a well-known proto-oncogene that has an important role in ribosomal function and in the regulation of protein …

MYC regulates the transcription of thousands of genes required to coordinate a range of cellular processes, including those essential for proliferation, growth, differentiation, apoptosis and self …

MYC stimulates transcription by RNA polymerases I and III, enhancing ribosome biogenesis and cell growth. Cancer therapies that target these transcriptional activities may impede tumor …

Apr 25, 2022 · The transcription factor Myc drives cell growth across animal phyla and is activated in most forms of human cancer. However, it is unclear which Myc target genes need to be …

Nov 1, 2003 · The proto-oncogene c- myc encodes a basic helix–loop–helix leucine zipper transcription factor (c-Myc) that has a profound role in growth control and cell cycle …

Mar 8, 2005 · These three reports provide evidence that Myc is a regulator of Pol I, directly in mammals and indirectly (through regulation of gene expression) in flies. Thus, Myc appears …

Jun 5, 2020 · With this review we outlined the evidence of Myc in controlling ribosome biogenesis with its role in cell competition, a hypothesis that may connect the ability of Myc to initiate …