Nov 28, 2006 · By integrating gene expression array and ChIP-on-chip data, we show that NOTCH1 directly activates multiple biosynthetic routes and induces c-MYC gene expression.

Mar 2, 2017 · Activation of NOTCH1 signaling in T-ALL is typically triggered by activating mutations in the NOTCH1 gene and loss of function mutations in FBXW7. NOTCH1 directly …

Starting from an expression-profiling screen, we identified c-myc as a direct target of Notch1 in Notch-dependent T-ALL cell lines, in which Notch accounts for the majority of c-myc expression.

Sep 7, 2014 · Here we identify a new long range–acting MYC enhancer controlled by NOTCH1 that is targeted by recurrent chromosomal duplications in human T cell acute lymphoblastic …

Feb 18, 2025 · Our results revealed that central and peripheral ES-SCLC had distinct responses to front-line treatments, potentially due to differential activation statuses of the MYC-Notch-non …

c-MYC expression is induced directly through NOTCH1, and the inhibition of NOTCH1 leads to cell cycle arrest, apoptosis, and reduced c-MYC levels . In T-ALL and NOTCH1-induced …

Oct 5, 2012 · NOTCH-MYC-induced resistance to PI3K/mTOR inhibition was supported by synergistic cell death induction by PI-103 and a small molecule c-MYC inhibitor, and by …

Mar 2, 2017 · Oncogenic NOTCH signaling, which is activated in more than 65% of T-ALL patients by activating mutations in the NOTCH1 gene, has emerged as a major regulator of …

Feb 16, 2022 · Bromodomain-containing protein 4 (BRD4) is implicated to have a role in the transcriptional regulation of oncogenes MYC and targets downstream of NOTCH1, and here …

All in all, we found that the activation of the MYC‐Notch‐non‐NE axis was connected to chemo‐resistance in ES‐SCLC, and DLL3, as a key inhibitory component of Notch signaling, …