Pathology Outlines - MYC
Jun 11, 2024 · Burkitt’s lymphoma: 90% have translocation of c-myc or variants; translocation causes continuous stimulation by adjacent enhancer element of immunoglobulin gene or …
MYC Immunohistochemistry to Identify MYC-Driven B-Cell …
Jan 29, 2016 · Objectives: Immunohistochemistry with anti-MYC antibody (MYC IHC) detects MYC protein in fixed samples of aggressive B-cell lymphomas and, according to the number of …
The Role of c-MYC in B-Cell Lymphomas: Diagnostic and …
In this review, we discuss the role that c-MYC plays in the pathogenesis of B-cell lymphomas, the molecular alterations that lead to c-MYC dysregulation, and their effect on prognosis and …
Immunohistochemical Detection of MYC-driven Diffuse Large B …
Herein, we report a standardized immunohistochemical (IHC) approach to assess MYC protein expression in formalin-fixed paraffin-embedded tissue (FFPE) which readily identifies DLBCLs …
MYC Immunohistochemistry Predicts MYC Rearrangements by …
Myc overexpression that results from dysregulation in the cell cycle of the Myc protein can be assayed by Western blot or immunohistochemistry (IHC) (15). There is increasing evidence …
MYC Immunohistochemistry to Identify MYC-Driven B-Cell
Feb 6, 2021 · Objectives: Immunohistochemistry with anti-MYC antibody (MYC IHC) detects MYC protein in fixed samples of aggressive B-cell lymphomas and, according to the number of …
Immunohistochemical pattern of c-MYC protein judged as "+/ …
Thus, FISH is not needed even if more than half of cells are c-MYC positive by PRIME notation. This is the first report describing a correspondence between immunohistochemical findings …
NordiQC - Immunohistochemical Quality Control
Apr 7, 2019 · IHC for c-MYC overexpression (>40%) is used to screen and predict c-MYC rearrangements and distinguish diffuse large B-cell lymphoma (DLBCL) NOS from high grade …
New MYC IHC Classifier Integrating Quantitative Architecture ...
A new automated MYC IHC classifier based on bivariate logistic regression is presented. The predictor relies on image analysis developed with the open-source ImageJ platform.
Immunohistochemical detection of MYC-driven diffuse large B-cell ...
Herein, we describe an immunohistochemical (IHC) method for identifying DLBCLs with increased MYC protein expression. We tested 77 cases of DLBCL and identified 15 cases with high MYC …