Though MYC levels are also controlled posttranscriptionally, our focus is on how the c-myc promoter works. c-myc is transcribed from promoters, P1 and P2, separated by 150 bp. Most transcripts initiate at P2.

Myc proteins are transcription factors that activate expression of many pro-proliferative genes through binding enhancer box sequences (E-boxes) and recruiting histone acetyltransferases (HATs).

Feb 19, 2025 · Anti-gene peptide nucleic acids (PNAs) hybridize with cDNA within the MYC gene promoter thereby blocking its transcription; MYC antisense oligonucleotides (MYCASOs) interfere with MYC mRNA ...

The transcription factor c-Myc is a key regulator of cell proliferation, cell growth, differentiation, and apoptosis. Deregulated c-myc expression possesses a high transformation potential and the proto-oncogene c-myc represents a promising target in anticancer therapy.

However, recent studies have identified numerous tissue-specific non-coding enhancers of MYC that play major roles in cancer, highlighting long-range transcriptional regulation of MYC as a critical novel mechanism leading to MYC hyperactivation and as a potential target for new therapeutic strategies in the near future.

Jun 29, 2021 · Central to the mechanism of MYC controlling core transcriptional processes is protein interactions that influence the epigenetic regulation of target genes, MYC promoter binding,...

The c-myc promoter is regulated by scores of signals, transcription factors, and chromatin components. The logic integrating these multiple signals remains unexplored.

Mar 7, 2024 · We propose that MYC drives prognostic cancer type-specific gene programs through induction of an enhancer-specific epigenetic switch, which can be targeted by BET and GCN5 inhibitors.

We engineered an optogenetic variant of MYC (Pi-MYC) and combined this tool with single-molecule RNA and protein imaging techniques to investigate the role of MYC in modulating transcriptional bursting and transcription factor binding dynamics in human cells.

Aug 9, 2021 · The nuclease hypersensitivity element III1 (NHE III1) located at the MYC promoter controls 80–90% of the transcriptional activity of MYC gene. A particular site of NHE III1 creates G-quadruplex acting as a silencer region [761].