The MYC proto-oncogenes encode a family of transcription factors that are among the most commonly activated oncoproteins in human neoplasias. Indeed, MYC aberrations or upregulation of MYC-related pathways by alternate mechanisms occur in the vast ...

Myc proteins are transcription factors that activate expression of many pro-proliferative genes through binding enhancer box sequences (E-boxes) and recruiting histone acetyltransferases (HATs).

MYC is a critical driver oncogene in many cancers, and its deregulation in the forms of translocation and overexpression has been implicated in lymphomagenesis and progression of diffuse large B-cell lymphoma (DLBCL). The MYC mutational profile and its …

Sep 10, 2021 · The MYC proto-oncogenes are among the most commonly activated proteins in human cancer, yet the clinical efficacy of MYC-targeted agents remains to be demonstrated.

Feb 26, 2019 · Myc is one of the most frequently mutated, widely studied, and overexpressed genes implicated in cancer. Most mutations in the myc gene lead to its constitutive expression. The myc gene...

Tabulated summary of genomic alterations (copy number alterations and mutations) in genes known to influence the expression of the MYC gene or regulate the MYC protein in 32 cancer types profiled by the TCGA.

Aug 9, 2021 · In this review, MYC regulation and the mechanisms by which MYC adjusts cellular functions and its implication in hematologic malignancies are summarized. Further, we also discuss potential inhibitors of MYC that could be beneficial for treating hematologic malignancies.

Although the MYC oncogene has been implicated in cancer, a systematic assessment of alterations of MYC, related transcription factors, and co-regulatory proteins, forming the proximal MYC network (PMN), across human cancers is lacking.

Jul 7, 2014 · We show that mutations in this region disrupt a second phosphodegron within MYC, and that they precisely phenocopy effects of mutations within MbI in terms of stability, enhanced tumorigenesis...

Nov 15, 2022 · MYC, a well-known oncogene, is implicated in a majority of cancers, but there is little data on its role in myeloid malignancies. We recently described a novel internal tandem duplication of MYC gene (MYC -ITD) in a subset of patients with AML.