Recent studies have identified a plethora of tissue-specific long-range enhancers of MYC that control its transcription in a tightly regulated-manner. These tissue-specific MYC enhancers are involved in normal development, in tumorigenesis or in both processes.

Mar 7, 2024 · We propose that MYC drives prognostic cancer type-specific gene programs through induction of an enhancer-specific epigenetic switch, which can be targeted by BET and GCN5 inhibitors. MYC is...

Jan 25, 2018 · We propose that clusters of enhancers, such as BENC, form highly combinatorial systems that allow precise control of gene expression across normal cellular hierarchies and which also can be hijacked in malignancies.

Jan 17, 2018 · We propose that clusters of enhancers, such as BENC, form highly combinatorial systems that allow precise control of gene expression across normal cellular hierarchies and which also can be...

May 10, 2024 · We identify a topologically-associated region that homes enhancers dedicated to Myc transcriptional regulation in stem cells of the pre-implantation and early post-implantation embryo.

A higher amount of MYC eRNA is observed in chronic pancreatitis and in pancreatic cancer patients. We show that MYC eRNA interacts with YEATS2, a histone reader protein of the ATAC-HAT complex, and augments the association of YEATS2-containing ATAC complexes with MYC promoter/enhancer regions and thus increases MYC gene expression.

2 days ago · NOTCH directly regulates MYC expression by binding to its enhancer and promoter and MYC is an essential mediator of NOTCH signaling controlling cell growth in T-ALL . Both NOTCH and MYC share numerous target genes, act synergistically, and compose a feed-forward loop promoting metabolism reprogramming, cellular growth, and determining cancer ...

Dec 16, 2024 · MYC deregulation occurs in the majority of multiple myeloma cases and is associated with progression and worse prognosis. Enhanced MYC expression occurs in about 70% of patients with multiple myeloma, but it is known to be driven by translocation or amplification events in only ∼40% of myelomas.

Mar 19, 2025 · The ChIP-qPCR analysis showed that MYC was enriched in the RAD23A promoter (Fig. 5G and H), enhancer E1, and E2 region (Fig. 5I and J) of A2780 and HO8910 cells, and the enrichment was more significant in their relative niraparib-resistant cells (Fig. 5K–M), indicating MYC as a key TF involved in the transcriptional regulation of RAD23A in ...

However, recent studies have identified numerous tissue-specific noncoding enhancers of MYC that play major roles in cancer, highlighting long-range transcriptional regulation of MYC as a critical novel mechanism leading to MYC hyperactivation and as a potential target for new therapeutic strategies in the near future.