Deciphering the Binding of the Nuclear Localization Sequence of Myc …
The oncoprotein Myc is a transcription factor regulating global gene expression and modulating cell proliferation, apoptosis, and metabolism. Myc has a nuclear localization sequence (NLS) …
Identifying and Validating MYC:Protein Interactors in Pursuit
In this chapter, we discuss four techniques to identify and validate MYC-interacting partners. First, we highlight BioID, a powerful discovery method used to identify high-confidence proximal …
MYC Protein Interactome Profiling Reveals Functionally Distinct …
Dec 6, 2018 · By conducting proteomic profiling of the MB interactomes, we demonstrate that half of the MYC interactors require one or more MBs for binding. Comprehensive phenotypic …
Structural and Biophysical Insights into the Function of the ...
Here, we review the cumulative knowledge on Myc structure and biophysics and discuss the implications for its biological function and the development of improved Myc inhibitors.
Multiple direct interactions of TBP with the MYC oncoprotein
Nov 4, 2019 · We propose that MYC-TBP interactions propagate transcription by modulating the energetic landscape of transcription initiation complex assembly. MYC contributes to more …
Large remodeling of the Myc-induced cell surface proteome in B …
Jan 1, 2021 · MYC is a powerful transcription factor and when overexpressed can drive cancers. We broadly characterized the MYC-driven surfaceome in B cells and prostate cells using …
Overlapping characteristics of weak interactions of two …
Here, we use biolayer interferometry (BLI) to examine interactions of WDR5 with consensus peptide ligands of MYC and RbBP5. We found that both interactions exhibit relatively weak …
Identifying and Validating MYC:Protein Interactors in ... - Springer
May 22, 2021 · By identifying MYC protein–protein interactors, we aim to gain a deeper mechanistic understanding of MYC as a regulator of gene transcription and potent …
Identifying and Validating MYC:Protein Interactors in Pursuit of …
May 25, 2021 · In this chapter, we discuss four techniques to identify and validate MYC-interacting partners. First, we highlight BioID, a powerful discovery method used to identify …
The MYC oncoprotein directly interacts with its chromatin cofactor ...
Apr 4, 2022 · MYC is a master-regulator that controls the transcription of ∼15% of genes, thereby regulating numerous biological processes associated with cancer initiation and progression, …
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