Myc Cooperates with Ras by Programming Inflammation and …
Nov 30, 2017 · In a mouse lung model of KRas G12D -driven adenomas, we find that co-activation of Myc drives the immediate transition to highly proliferative and invasive …
RAS and MYC: Co-conspirators in Cancer - NCI - National Cancer …
Jul 13, 2017 · Although the posttranslational regulation of MYC can significantly contribute to RAS-driven cancer and to resistance to interventions targeting RAS signaling, many questions …
MYC Drives Progression of Small Cell Lung Cancer to a Variant ...
Feb 13, 2017 · We show that Myc expression cooperates with Rb1 and Trp53 loss in the mouse lung to promote aggressive, highly metastatic tumors, that are initially sensitive to …
Epigenetic Therapy Ties MYC Depletion to Reversing Immune
Nov 30, 2017 · Using in-vitro-treated NSCLC cell lines, we elucidate an interferon α/β-based transcriptional program with accompanying upregulation of antigen presentation machinery, …
The long journey to bring a Myc inhibitor to the clinic - PMC
Myc is a nuclear transcription factor that coordinates intracellular and extracellular programs that allow cells to divide in an orderly manner. The Myc family consists of three functionally related …
MYC—an emerging player in mitochondrial diseases - PMC
MYC (c-MYC, avian MYeloCytomatosis viral oncogene homolog) is a Basic-Helix-Loop-Helix-Leucine Zipper (bHLHZip)-family transcription factor that regulates a broad range of cellular …
Critical role of Myc activation in mouse hepatocarcinogenesis induced ...
May 8, 2017 · Here we examined the role of Myc activation in mouse liver tumours induced by hepatocytic expression of myristoylated AKT (AKT) and/or mutant HRASV12 (HRAS) via …
Human Cancer Cells Signal Their Competitive Fitness Through MYC ...
Oct 3, 2017 · Altogether, our findings suggest that the innate role of MYC-mediated cell competition in development is conserved in human cancer, with malignant cells using MYC …
(PDF) Myc Cooperates with Ras by Programming ... - ResearchGate
Jul 5, 2022 · In a mouse lung model of KRasG12D-driven adenomas we find that co-activation of Myc drives the immediate transition to highly proliferative and invasive adenocarcinomas …
MYC regulation of glutamine–proline regulatory axis is key
Nov 23, 2017 · Altered cellular metabolism is a hallmark of cancer and some are reliant on glutamine for sustained proliferation and survival. We hypothesise that the glutamine–proline …