May 1, 2009 · The small molecular weight G-protein RAB7 is localized to both early and late endosomes and has been shown to be critical for trafficking through the endocytic pathway. …

May 1, 2022 · Knockdown of Rab7 Does Not Affect Transferrin Receptor Recycling—To determine whether RAB7 was required for recycling from the early endosome, rather than …

Aug 18, 2023 · Rab7 is present on the LE/MVB and is required for the fusion between the LE/MVB and the lysosome 24. It is also involved in regulating autophagosome-lysosome …

Rab7 – or in yeast, Ypt7p – governs membrane trafficking in the late endocytic and autophagic pathways. Rab7 also regulates mitochondrion-lysosome contacts, the sites of mitochondrial …

Importantly, Rab7 is dramatically activated in cells placed under nutrient stress; this activation is required for the trafficking of both multivesicular bodies (MVBs) and lysosomes to the LD …

In the absence of RAB7, trafficking of the EGF EGFR complex through the early endosome to the late endosome/multivesicular body (LE/MVB) does not change, but exiting from the LE/MVB is …

Mar 29, 2019 · Using proteome-wide ubiquitin remnant profiling, we reveal Rab7 to be a key substrate of USP32 and go on to show that USP32 supports Rab7 functions in transport and …

Mar 15, 2015 · In this study, we have found that by activating Rab7a, HBV alters its own secretion by inducing dramatic changes in the morphology of MVB and autophagic compartments.

Neddylated Coro1a is associated with the MVB membrane and facilitates MVB recruitment and activation of Rab7 by directly binding Rab7. Subsequently, MVBs are targeted to lysosomes …

Mar 1, 2011 · Rabring7 (Rab7-interacting ring-finger protein), a candidate E3 ligase, is associated with breast cancer cell invasion and regulates EGFR degradation [17], [18]. Rab7 may also …