MUM1/ IRF4 is the abbreviation of multiple myeloma 1 / interferon regulatory factor 4 and is a nuclear marker that is normally expressed in activated B and T cells, plasma cells and melanocytes.

MUM1, IHC with Interpretation - Multiple myeloma oncogene-1 (MUM1) is a 50 kDa protein encoded by the MUM1 gene. IRF4/MUM1 is expressed in the nuclei and cytoplasm of plasma cells and a small percentage of germinal center (GC) B cells located in the "light zone".

Aids in the identification of hematolymphoid neoplasms and melanomas. For the initial technical component only immunohistochemical (IHC) stain performed, the appropriate bill-only test ID will be reflexed and charged (IHTOI).

MUM-1 (multiple myeloma oncogene-1), expressed by the IRF4 gene, is seen in a subset of B cells in the light zone of the germinal center (representing late stages of B cell differentiation), plasma cells, activated T cells, and a variety of hematolymphoid neoplasms …

Dysregulation of the IRF4 gene can result in IRF4 functioning either as an oncogene or a tumor-suppressor, depending on the context of the modification. [8] The MUM1 symbol is also the current HGNC official symbol for melanoma associated antigen (mutated) 1 (HGNC:29641).

MUM1 is a gene primarily identified in Multiple Myeloma cell line where it was localized in region of chromosomal translocations t (6;14) (p25;q32) placing this gene in proximity of IgH enhancer locus.

Multiple Myeloma Oncogene 1 (MUM-1) is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

MUM-1 (multiple myeloma oncogene-1), expressed by the IRF4 gene, is seen in a subset of B cells in the light zone of the germinal center (representing late stages of B cell differentiation), plasma cells, activated T cells, and a variety of hematolymphoid neoplasms …

Purpose: The current gold standard for chronic endometritis (CE) diagnosis is immunohistochemistry (IHC) for CD-138. However, IHC for CD-138 is not exempt from diagnostic limitations. The aim of our study was to evaluate the reliability and accuracy of MUM-1 IHC, as compared with CD-138.

Immunohistochemistry (IHC) for MUM1 has been widely used to support the diagnosis of lymphomas such as cHL, ALCL and plasma cell tumors. Besides, MUM1 was reported for the diagnosis of cHL with high sensitivity and specificity and expressed in …