Mar 30, 2025 · MUC7 (Mucin 7, Secreted) is a Protein Coding gene. Diseases associated with MUC7 include Asthma and Chronic Ethmoiditis. Among its related pathways are O-linked glycosylation of mucins and Metabolism of proteins.

Mucin-7 is a protein that in humans is encoded by the MUC7 gene. [3][4] In animals, the MUC7 gene is found in most placental mammals, but not marsupials. [5] Humans carry either a five or six tandem repeat version of the gene.

MUC7 is a small secreted mucin, found mainly in saliva and the respiratory tract, which does not share significant homology with the chromosome 11 family and MUC19, and does not homopolymerize via disulfide bonds.

Aug 25, 2016 · Our results establish MUC7 as a major player in salivary adaptation, likely as a response to diverse pathogenic exposure in primates. On a broader scale, our study highlights variable...

Feb 25, 2025 · Biological evaluations reveal that different glycoforms of synthetic MUC7 glycopeptides mediate unique activities against biofilm formation of Pseudomonas aeruginosa, among which sialylated MUC7 glycopeptide exhibits better inhibitory activity and has the potential to develop antibacterial drugs.

Jan 4, 2025 · Title: Absence of capsule reveals glycan-mediated binding and recognition of salivary mucin MUC7 by Streptococcus pneumoniae. Submit: New GeneRIF Correction See all GeneRIFs (32) Phenotypes

MUC7 is a salivary mucin with antimicrobial activity against bacteria and fungi. A significant increase in sulfation was identified in salivary MUC7 from rheumatoid arthritis patients. The study did not show a correlation between the MUC7 genotypes and caries.

Human salivary mucin (MUC7) is characterized by a single polypeptide chain of 357 aa. Detailed analysis of the derived MUC7 peptide sequence reveals five distinct regions or domains: (1) an N-terminal basic, histatin-like domain which has a leucine-zipper segment, (2) a moderately glycosylated domai …

Oct 10, 2023 · This gene encodes a small salivary mucin, which is thought to play a role in facilitating the clearance of bacteria in the oral cavity and to aid in mastication, speech, and swallowing. The central domain of this glycoprotein contains tandem …

We have previously shown that MUC7 (human salivary low-molecular-mass mucin) 20-mer: LAHQKPFIRKSYKCLHKRCR (residues 32-51 of the parent MUC7, with a net positive charge of 7) possesses a broad-spectrum antimicrobial activity [Bobek and Situ (2003) Antimicrob. Agents Chemother. 47, 645-652].