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The EGF Domains of MUC4 Oncomucin Mediate HER2 Binding
Nov 16, 2021 · The HER2 receptor and its MUC4 mucin partner form an oncogenic complex via an extracellular region of MUC4 encompassing three EGF domains that promotes tumor …
- Author: Nicolas Stoup, Maxime Liberelle, Céline Schulz, Sumeyye Cavdarli, Romain Vasseur, Romain Magnez, Fat...
- Publish Year: 2021
The EGF Domains of MUC4 Oncomucin Mediate HER2 Binding …
In this study, we specified the binding mode of MUC4 EGF domains with HER2 and demonstrate their “growth factor-like” biological activities in PC cells leading to stimulation of several …
MUC4 activates HER2 signalling and enhances the motility of …
Jul 29, 2008 · Reciprocal co-immunoprecipitation revealed an interaction of MUC4 with HER2. Further, the MUC4-overexpressing SKOV3 cells exhibited an increase in the phosphorylation …
- Author: Moorthy Palanimuthu Ponnusamy, A. P. Singh, Maneesh Jain, S. Chakraborty, N. Moniaux, Surinder Kumar...
- Publish Year: 2008
MUC4 activates HER2 signalling and enhances the motility of …
Aug 5, 2008 · Reciprocal co-immunoprecipitation revealed an interaction of MUC4 with HER2. Further, the MUC4-overexpressing SKOV3 cells exhibited an increase in the phosphorylation …
- Author: Moorthy Palanimuthu Ponnusamy, A. P. Singh, Maneesh Jain, S. Chakraborty, N. Moniaux, Surinder Kumar...
- DOI: 10.1038/sj.bjc.6604517
- Publish Year: 2008
- Publication: Br J Cancer. 2008 Aug 5; 99(3): 520-526.
MUC4 stabilizes HER2 expression and maintains the …
The exogenous MUC4 expression in ovarian cancer cells showed an increase in HER2 expression and colocalization, suggesting that MUC4 is involved in the stabilization of HER2 protein. There is emerging evidence that small …
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MUC4 mucin interacts with and stabilizes the HER2 oncoprotein
Apr 1, 2008 · In the present study, we have shown the interaction of human MUC4 with the receptor tyrosine kinase HER2 in pancreatic adenocarcinoma cells by reciprocal …
Structure, evolution, and biology of the MUC4 mucin - PMC
MUC4 colocalizes and physically interacts with the receptor tyrosine kinase HER2 in pancreatic cancer cells (unpublished data). HER2 is a member of the epidermal growth factor receptor …
MUC4 stabilizes HER2 expression and maintains the cancer stem …
Apr 26, 2011 · The exogenous MUC4 expression in ovarian cancer cells showed an increase in HER2 expression and colocalization, suggesting that MUC4 is involved in the stabilization of …
MUC4-Mediated Regulation of Acute Phase Protein …
Feb 2, 2014 · Experimental Designs and Results: Overexpression/knockdown, luciferase reporter and molecular inhibition studies revealed that MUC4 regulates lipocalin 2 by stabilizing HER2 and stimulating AKT, which results in the …
