Mucin-4 (MUC-4) is a mucin protein that in humans is encoded by the MUC4 gene. [3] Like other mucins, MUC-4 is a high-molecular weight glycoprotein. [4] The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These ...

Mar 30, 2025 · MUC4 (Mucin 4, Cell Surface Associated) is a Protein Coding gene. Diseases associated with MUC4 include Biliary Tract Cancer and Adenosquamous Carcinoma. Among its related pathways are O-linked glycosylation of mucins and Metabolism of proteins.

MUC4, a member of transmembrane mucin family, is expressed in airway epithelial cells and body fluids like saliva, tear film, ear fluid, and breast milk. In addition to its normal expression, an aberrant expression of MUC4 has been reported in a variety of carcinomas.

MUC4, a membrane-bound mucin encoded by a gene located on chromosome locus 3q29, is aberrantly expressed in several cancers including those of the bile duct, breast, colon, esophagus, ovary, lung, prostate, stomach and pancreas.

MUC4 imparting resistance to pancreatic cancer cells against gemcitabine through the activation of anti-apoptotic pathways and, thereby, promoting cell survival. MUC4 is a lineage marker in benign cervical tissue that may have aberrant expression in squamous dysplasia and carcinoma

The membrane mucin MUC4 (human) is abundantly expressed in many epithelia, where it is proposed to play a protective role, and is overexpressed in some epithelial tumors. Studies on the rat homologue, Muc4, indicate that it acts through anti-adhesive or signaling mechanisms.

Mucin-4 (MUC4), a transmembrane mucin, is critical in epithelial renewal and differentiation. Recent research indicates that MUC4 is involved in pancreatic cancer etiology and is expressed in a variety of normal and malignant tissues.

Feb 8, 2025 · These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist.

MUC4 is synthesized as a precursor cleaved in two subunits that remain non-covalently link to each other: the mucin type subunit MUC4a of 850 kDa and the membrane-bound growth factor like subunit MUC4b of 80 kDa. MUC4 is a modular protein, composed of very distinct domains.

MUC4 is a membrane-bound mucin, a type of highly glycosylated protein that forms a major component of mucus, the viscous substance covering epithelial surfaces. MUC4 plays a crucial role in protecting the epithelium and is involved in its renewal and differentiation.