Nov 9, 2023 · We hypothesized that targeting HER3 and MUC1 simultaneously with bispecific antibody drug conjugates (bsADCs) may potentially allow enhanced potency, reduced …

Apr 10, 2023 · Mechanistically, MUC1-C integrates induction of MYC in driving cell cycle progression with activation of the SHP2 phosphotyrosine phosphatase, which enhances RTK …

We report here the generation of mAb 3D1 against the nonshed oncogenic MUC1 C-terminal (MUC1-C) subunit. We show that mAb 3D1 binds with low nM affinity to the MUC1-C …

Recent studies in pancreatic cancer treatment demonstrate that targeting tumor-associated MUC1 (tMUC1) with the monoclonal antibody TAB004 overcomes anoikis resistance by specifically …

The transmembrane glycoprotein Mucin 1 (MUC1) is aberrantly glycosylated and overexpressed in a variety of epithelial cancers, and plays a crucial role in progression of the disease. Tumor …

Oct 1, 2005 · We have examined 1447 cases of invasive breast carcinoma with a long-term follow-up, using tissue microarray (TMA) technology and immunohistochemistry to evaluate …

Apr 11, 2024 · Here we generated fully human antibodies against both HER3 and MUC1-C targeting the juxtamembrane domain of MUC1 (MUC1-C) to avoid the interference of MUC1 …

Apr 10, 2023 · We show that BRAF (V600E) CRC cells are dependent on MUC1-C for proliferation and BRAF inhibitor (BRAFi) resistance. Mechanistically, MUC1-C integrates …

We generated antibodies for both HER3 and MUC1 in RenLite® fully human antibody mice, which contain a common light chain to facilitate bispecific antibody assembly.

MUC1 can promote oxidative stress levels and inflammatory responses in macrophages. To investigate the effect mechanism of MUC1 on RIF. We transfected pLV-MUC1 and negative …